Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice

Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice

Abstract Clinical and genetic research links altered cholesterol metabolism with ALS development and progression, yet pinpointing specific pathomechanisms remain challenging. We investigated how cholesterol dysmetabolism interacts with protein aggregation, demyelination, and neuronal loss in ALS. Bu...

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Main Authors: Ali Rezaei, Virág Kocsis-Jutka, Zeynep I. Gunes, Qing Zeng, Georg Kislinger, Franz Bauernschmitt, Huseyin Berkcan Isilgan, Laura R. Parisi, Tuğberk Kaya, Sören Franzenburg, Jonas Koppenbrink, Julia Knogler, Thomas Arzberger, Daniel Farny, Brigitte Nuscher, Eszter Katona, Ashutosh Dhingra, Chao Yang, Garyfallia Gouna, Katherine D. LaClair, Aleksandar Janjic, Wolfgang Enard, Qihui Zhou, Nellwyn Hagan, Dimitry Ofengeim, Eduardo Beltrán, Ozgun Gokce, Mikael Simons, Sabine Liebscher, Dieter Edbauer
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58634-4
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