Characteristics of Hepatitis C Virus Infection in HIV-Infected People
Knowledge pertaining to hepatitis C virus (HCV)/human immunodeficiency virus (HIV) co-infection is currently incomplete or conflicting. Several points are well studied, however. Plasma HCV RNA levels are higher in matched HIV-infected people than in HIV-seronegative control subjects and are inversel...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2001/542056 |
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| _version_ | 1832549388424052736 |
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| author | Curtis L Cooper Andrew D Badley Jonathan B Angel |
| author_facet | Curtis L Cooper Andrew D Badley Jonathan B Angel |
| author_sort | Curtis L Cooper |
| collection | DOAJ |
| description | Knowledge pertaining to hepatitis C virus (HCV)/human immunodeficiency virus (HIV) co-infection is currently incomplete or conflicting. Several points are well studied, however. Plasma HCV RNA levels are higher in matched HIV-infected people than in HIV-seronegative control subjects and are inversely correlated with CD4+ T lymphocyte counts. HCV genotype does not appear to influence this value. Co-infected individuals develop histological and clinical features of HCV liver disease more rapidly than HIV-seronegative patients. Co-infected individuals appear to respond to interferon-alpha therapy equally as well as HIV-seronegative HCV-infected adults, but minimal information exists regarding the efficacy and toxicity of combination HCV therapy (interferon-alpha plus ribavirin) in this population. Adverse consequences of highly active antiretroviral therapy in co-infected patients include hepatic toxicity and, in a minority of patients, an 'immune restoration syndrome'. It is unclear whether long term, highly active antiretroviral therapy positively or negatively influences the natural history of HCV infection. |
| format | Article |
| id | doaj-art-8201fa2ec4854a998a882589ab7f4719 |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-8201fa2ec4854a998a882589ab7f47192025-02-03T06:11:29ZengWileyCanadian Journal of Infectious Diseases1180-23322001-01-0112315716310.1155/2001/542056Characteristics of Hepatitis C Virus Infection in HIV-Infected PeopleCurtis L CooperAndrew D BadleyJonathan B AngelKnowledge pertaining to hepatitis C virus (HCV)/human immunodeficiency virus (HIV) co-infection is currently incomplete or conflicting. Several points are well studied, however. Plasma HCV RNA levels are higher in matched HIV-infected people than in HIV-seronegative control subjects and are inversely correlated with CD4+ T lymphocyte counts. HCV genotype does not appear to influence this value. Co-infected individuals develop histological and clinical features of HCV liver disease more rapidly than HIV-seronegative patients. Co-infected individuals appear to respond to interferon-alpha therapy equally as well as HIV-seronegative HCV-infected adults, but minimal information exists regarding the efficacy and toxicity of combination HCV therapy (interferon-alpha plus ribavirin) in this population. Adverse consequences of highly active antiretroviral therapy in co-infected patients include hepatic toxicity and, in a minority of patients, an 'immune restoration syndrome'. It is unclear whether long term, highly active antiretroviral therapy positively or negatively influences the natural history of HCV infection.http://dx.doi.org/10.1155/2001/542056 |
| spellingShingle | Curtis L Cooper Andrew D Badley Jonathan B Angel Characteristics of Hepatitis C Virus Infection in HIV-Infected People Canadian Journal of Infectious Diseases |
| title | Characteristics of Hepatitis C Virus Infection in HIV-Infected People |
| title_full | Characteristics of Hepatitis C Virus Infection in HIV-Infected People |
| title_fullStr | Characteristics of Hepatitis C Virus Infection in HIV-Infected People |
| title_full_unstemmed | Characteristics of Hepatitis C Virus Infection in HIV-Infected People |
| title_short | Characteristics of Hepatitis C Virus Infection in HIV-Infected People |
| title_sort | characteristics of hepatitis c virus infection in hiv infected people |
| url | http://dx.doi.org/10.1155/2001/542056 |
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