COVID-19 vaccine effectiveness among South Asians in Canada.
We evaluated the effectiveness of COVID-19 vaccines among South Asians living in Ontario, Canada compared to non-South Asians and compared the odds of symptomatic COVID-19 infection and related hospitalizations and deaths among non-vaccinated South Asians and non-South Asians. This was a test negati...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLOS Global Public Health |
| Online Access: | https://doi.org/10.1371/journal.pgph.0003490 |
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| author | Rahul Chanchlani Baiju R Shah Shrikant I Bangdiwala Russell J de Souza Jin Luo Shelly Bolotin Dawn M E Bowdish Dipika Desai Karl Everett Scott A Lear Mark Loeb Zubin Punthakee Diana Sherifali Gita Wahi Sonia S Anand |
| author_facet | Rahul Chanchlani Baiju R Shah Shrikant I Bangdiwala Russell J de Souza Jin Luo Shelly Bolotin Dawn M E Bowdish Dipika Desai Karl Everett Scott A Lear Mark Loeb Zubin Punthakee Diana Sherifali Gita Wahi Sonia S Anand |
| author_sort | Rahul Chanchlani |
| collection | DOAJ |
| description | We evaluated the effectiveness of COVID-19 vaccines among South Asians living in Ontario, Canada compared to non-South Asians and compared the odds of symptomatic COVID-19 infection and related hospitalizations and deaths among non-vaccinated South Asians and non-South Asians. This was a test negative design study conducted in Ontario, Canada between December 14, 2020 and November 15, 2021. All eligible individuals >18 years with symptoms of COVID-19 were subdivided by ethnicity (South Asian vs other) and vaccination status (vaccinated versus not). The primary outcome was vaccine effectiveness as defined by COVID-19 infections, hospitalizations, and deaths, and secondary outcome was the odds of COVID-19 infections, hospitalizations, and death comparing non-vaccinated South Asians to non-vaccinated non-South Asians. 883,155 individuals were included. Among South Asians, two doses of COVID-19 vaccine prevented 93.8% (95% CI 93.2, 94.4) of COVID-19 infections and 97.5% (95% CI 95.2, 98.6) of hospitalizations and deaths. Among non-South Asians, vaccines prevented 86.6% (CI 86.3, 86.9) of COVID-19 infections and 93.1% (CI 92.2, 93.8) of hospitalizations and deaths. Non-vaccinated South Asians had higher odds of symptomatic SARS-CoV-2 infection compared to non-vaccinated non-South Asians (OR 2.35, 95% CI 2.3, 2.4), regardless of their immigration status. COVID-19 vaccines are effective in preventing infections, hospitalizations and deaths among South Asians living in Canada. The observation that non-vaccinated South Asians have higher odds of symptomatic COVID-19 infection warrants further investigation. |
| format | Article |
| id | doaj-art-81fe266bf1de4e0c8126ee4e5cf76092 |
| institution | DOAJ |
| issn | 2767-3375 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj-art-81fe266bf1de4e0c8126ee4e5cf760922025-08-20T02:47:03ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752024-01-0148e000349010.1371/journal.pgph.0003490COVID-19 vaccine effectiveness among South Asians in Canada.Rahul ChanchlaniBaiju R ShahShrikant I BangdiwalaRussell J de SouzaJin LuoShelly BolotinDawn M E BowdishDipika DesaiKarl EverettScott A LearMark LoebZubin PunthakeeDiana SherifaliGita WahiSonia S AnandWe evaluated the effectiveness of COVID-19 vaccines among South Asians living in Ontario, Canada compared to non-South Asians and compared the odds of symptomatic COVID-19 infection and related hospitalizations and deaths among non-vaccinated South Asians and non-South Asians. This was a test negative design study conducted in Ontario, Canada between December 14, 2020 and November 15, 2021. All eligible individuals >18 years with symptoms of COVID-19 were subdivided by ethnicity (South Asian vs other) and vaccination status (vaccinated versus not). The primary outcome was vaccine effectiveness as defined by COVID-19 infections, hospitalizations, and deaths, and secondary outcome was the odds of COVID-19 infections, hospitalizations, and death comparing non-vaccinated South Asians to non-vaccinated non-South Asians. 883,155 individuals were included. Among South Asians, two doses of COVID-19 vaccine prevented 93.8% (95% CI 93.2, 94.4) of COVID-19 infections and 97.5% (95% CI 95.2, 98.6) of hospitalizations and deaths. Among non-South Asians, vaccines prevented 86.6% (CI 86.3, 86.9) of COVID-19 infections and 93.1% (CI 92.2, 93.8) of hospitalizations and deaths. Non-vaccinated South Asians had higher odds of symptomatic SARS-CoV-2 infection compared to non-vaccinated non-South Asians (OR 2.35, 95% CI 2.3, 2.4), regardless of their immigration status. COVID-19 vaccines are effective in preventing infections, hospitalizations and deaths among South Asians living in Canada. The observation that non-vaccinated South Asians have higher odds of symptomatic COVID-19 infection warrants further investigation.https://doi.org/10.1371/journal.pgph.0003490 |
| spellingShingle | Rahul Chanchlani Baiju R Shah Shrikant I Bangdiwala Russell J de Souza Jin Luo Shelly Bolotin Dawn M E Bowdish Dipika Desai Karl Everett Scott A Lear Mark Loeb Zubin Punthakee Diana Sherifali Gita Wahi Sonia S Anand COVID-19 vaccine effectiveness among South Asians in Canada. PLOS Global Public Health |
| title | COVID-19 vaccine effectiveness among South Asians in Canada. |
| title_full | COVID-19 vaccine effectiveness among South Asians in Canada. |
| title_fullStr | COVID-19 vaccine effectiveness among South Asians in Canada. |
| title_full_unstemmed | COVID-19 vaccine effectiveness among South Asians in Canada. |
| title_short | COVID-19 vaccine effectiveness among South Asians in Canada. |
| title_sort | covid 19 vaccine effectiveness among south asians in canada |
| url | https://doi.org/10.1371/journal.pgph.0003490 |
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