Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial Pneumonia
Idiopathic nonspecific interstitial pneumonia (iNSIP) is recognized as a distinct entity among various types of idiopathic interstitial pneumonias. It is identified histologically by the nonspecific interstitial pneumonia pattern. A diagnosis of iNSIP is feasible once secondary causes or underlying...
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| Language: | English |
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The Korean Academy of Tuberculosis and Respiratory Diseases
2025-04-01
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| Series: | Tuberculosis and Respiratory Diseases |
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| Online Access: | http://e-trd.org/upload/pdf/trd-2024-0168.pdf |
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| author | Yong Suk Jo Hyun-Kyung Lee Sun Hyo Park Joon Sung Joh Hye Jin Jang Jong Sun Park |
| author_facet | Yong Suk Jo Hyun-Kyung Lee Sun Hyo Park Joon Sung Joh Hye Jin Jang Jong Sun Park |
| author_sort | Yong Suk Jo |
| collection | DOAJ |
| description | Idiopathic nonspecific interstitial pneumonia (iNSIP) is recognized as a distinct entity among various types of idiopathic interstitial pneumonias. It is identified histologically by the nonspecific interstitial pneumonia pattern. A diagnosis of iNSIP is feasible once secondary causes or underlying diseases are ruled out. Usually presenting with respiratory symptoms such as shortness of breath and cough, iNSIP has a subacute or chronic course. It predominantly affects females aged 50 to 60 years who are non-smokers. Key imaging findings on chest high-resolution computed tomography include bilateral reticular opacities in lower lungs, traction bronchiectasis, reduced lung volumes and, ground-glass opacities. Abnormalities are typically diffuse across both lungs with subpleural distributions. Treatment often involves systemic steroids, either alone or in combination with other immunosuppressants, although evidence supporting effectiveness of these treatments is limited. Prognosis is generally more favorable for iNSIP than for idiopathic pulmonary fibrosis, with many studies reporting a 5-year survival rate above 70%. Antifibrotic agents should be considered in a condition, termed progressive pulmonary fibrosis, where pulmonary fibrosis progressively worsens. |
| format | Article |
| id | doaj-art-81fcde7ca7cd49909c917b0e40a88fac |
| institution | OA Journals |
| issn | 1738-3536 2005-6184 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | The Korean Academy of Tuberculosis and Respiratory Diseases |
| record_format | Article |
| series | Tuberculosis and Respiratory Diseases |
| spelling | doaj-art-81fcde7ca7cd49909c917b0e40a88fac2025-08-20T02:08:12ZengThe Korean Academy of Tuberculosis and Respiratory DiseasesTuberculosis and Respiratory Diseases1738-35362005-61842025-04-0188223724610.4046/trd.2024.01684913Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial PneumoniaYong Suk Jo0Hyun-Kyung Lee1Sun Hyo Park2Joon Sung Joh3Hye Jin Jang4Jong Sun Park5 Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea Division of Pulmonology, Respiratory Center, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Republic of Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Republic of Korea Division of Pulmonology, Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Republic of Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of KoreaIdiopathic nonspecific interstitial pneumonia (iNSIP) is recognized as a distinct entity among various types of idiopathic interstitial pneumonias. It is identified histologically by the nonspecific interstitial pneumonia pattern. A diagnosis of iNSIP is feasible once secondary causes or underlying diseases are ruled out. Usually presenting with respiratory symptoms such as shortness of breath and cough, iNSIP has a subacute or chronic course. It predominantly affects females aged 50 to 60 years who are non-smokers. Key imaging findings on chest high-resolution computed tomography include bilateral reticular opacities in lower lungs, traction bronchiectasis, reduced lung volumes and, ground-glass opacities. Abnormalities are typically diffuse across both lungs with subpleural distributions. Treatment often involves systemic steroids, either alone or in combination with other immunosuppressants, although evidence supporting effectiveness of these treatments is limited. Prognosis is generally more favorable for iNSIP than for idiopathic pulmonary fibrosis, with many studies reporting a 5-year survival rate above 70%. Antifibrotic agents should be considered in a condition, termed progressive pulmonary fibrosis, where pulmonary fibrosis progressively worsens.http://e-trd.org/upload/pdf/trd-2024-0168.pdfinterstitial lung diseaseidiopathic nonspecific interstitial pneumoniadiagnosismanagement |
| spellingShingle | Yong Suk Jo Hyun-Kyung Lee Sun Hyo Park Joon Sung Joh Hye Jin Jang Jong Sun Park Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial Pneumonia Tuberculosis and Respiratory Diseases interstitial lung disease idiopathic nonspecific interstitial pneumonia diagnosis management |
| title | Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial Pneumonia |
| title_full | Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial Pneumonia |
| title_fullStr | Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial Pneumonia |
| title_full_unstemmed | Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial Pneumonia |
| title_short | Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial Pneumonia |
| title_sort | korean guidelines for diagnosis and management of idiopathic nonspecific interstitial pneumonia |
| topic | interstitial lung disease idiopathic nonspecific interstitial pneumonia diagnosis management |
| url | http://e-trd.org/upload/pdf/trd-2024-0168.pdf |
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