Single-cell RNA sequencing reveals the intra-tumoral heterogeneity and immune microenvironment of small cell carcinoma of the ovary, hypercalcemic type

Single-cell RNA sequencing reveals the intra-tumoral heterogeneity and immune microenvironment of small cell carcinoma of the ovary, hypercalcemic type

Abstract Purpose Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and lethal cancer lacking effective treatment. Its genomic mutations and tumor microenvironment need further exploration. Methods We performed whole-exome sequencing or gene panel test to explore the SMARCA4 mu...

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Bibliographic Details
Main Authors: Yi Gao, Kewei Zheng, Haowen Tan, Mingyi Kang, Bingjian Lu, Ling Chen, Jing Xu, Chong Lu, Ranran Chai, Congjian Xu, Yu Kang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Ovarian Research
Subjects:
SMARCA4
SCCOHT
Intra-tumoral heterogeneity
Immune microenvironment
Online Access:https://doi.org/10.1186/s13048-025-01649-8
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