Can Cobalamin prevent Oxaliplatin induced peripheral neuropathy?
Background and objectives:Peripheral neuropathy induced by oxaliplatin is one of the main reasons for discontinuing chemotherapy. In this article, we evaluated the role of vitamin B12 in the prevention of oxaliplatin-induced peripheral neuropathy. Methods: A prospective randomized interventional...
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Kurdistan Higher Council Of Medical Specialties
2023-06-01
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| Series: | Advanced Medical Journal |
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| Online Access: | https://amj.khcms.edu.krd/index.php/main/article/view/242 |
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| author | Naza Shakir Shareef Shekhany Jangi Shawkat Salai |
| author_facet | Naza Shakir Shareef Shekhany Jangi Shawkat Salai |
| author_sort | Naza Shakir Shareef Shekhany |
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Background and objectives:Peripheral neuropathy induced by oxaliplatin is one of the main reasons for discontinuing chemotherapy. In this article, we evaluated the role of vitamin B12 in the prevention of oxaliplatin-induced peripheral neuropathy.
Methods: A prospective randomized interventional study was done from 1st January 2018 to 30th De- cember 2018, in which patients who were diagnosed with gastrointestinal cancer in Rizgary and Nanakali teaching hospitals that have been scheduled to receive oxaliplatin-based regimen were enrolled. Patients were divided into two groups: control group received chemotherapy only and prophylaxis group received chemotherapy with vitamin B12; each group included fifteen patients with no significant differences between the groups regarding age and gender. The prophylaxis group received vitamin B12 injection in scheduled periods. All Patients received at least a cumulative dose of 500 mg/m2 of oxaliplatin. Patients were evaluated by nerve conduction study, B12 level, and other laboratory tests.
Results: Twenty-one patients completed the study. There was a significant decrease in the serum vitamin B12 level (601.84±398.43 to 363±337.31) post-chemotherapy among the control group. Among the prophylaxis group, the mean value of serum vitamin B12 increased significantly after chemotherapy. To summarize, there was a significant decrease in the amplitude of nerve conduction study in the control group as compared to the prophylaxis group espe- cially in left (11.85±6.84 to 8.14±5.36) and right (14.01±6.05 to 9.52±6.08) Sural nerves.
Conclusions:Vitamin B12 injection had an important role in the prevention of development of chronic oxaliplatin-induced peripheral neuropathy.
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| format | Article |
| id | doaj-art-81f2c6479147409ea6657fbd7045fe03 |
| institution | OA Journals |
| issn | 2958-8979 2957-3580 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Kurdistan Higher Council Of Medical Specialties |
| record_format | Article |
| series | Advanced Medical Journal |
| spelling | doaj-art-81f2c6479147409ea6657fbd7045fe032025-08-20T02:17:34ZengKurdistan Higher Council Of Medical SpecialtiesAdvanced Medical Journal2958-89792957-35802023-06-015210.56056/amj.2019.102243Can Cobalamin prevent Oxaliplatin induced peripheral neuropathy?Naza Shakir Shareef Shekhany0Jangi Shawkat Salai1Department of pharmacology, college of pharmacy, Hawler medical university, Erbil, Iraq.Department of Pharmacology and Biophysics, college of medicine, Hawler medical university, Erbil, Iraq. Background and objectives:Peripheral neuropathy induced by oxaliplatin is one of the main reasons for discontinuing chemotherapy. In this article, we evaluated the role of vitamin B12 in the prevention of oxaliplatin-induced peripheral neuropathy. Methods: A prospective randomized interventional study was done from 1st January 2018 to 30th De- cember 2018, in which patients who were diagnosed with gastrointestinal cancer in Rizgary and Nanakali teaching hospitals that have been scheduled to receive oxaliplatin-based regimen were enrolled. Patients were divided into two groups: control group received chemotherapy only and prophylaxis group received chemotherapy with vitamin B12; each group included fifteen patients with no significant differences between the groups regarding age and gender. The prophylaxis group received vitamin B12 injection in scheduled periods. All Patients received at least a cumulative dose of 500 mg/m2 of oxaliplatin. Patients were evaluated by nerve conduction study, B12 level, and other laboratory tests. Results: Twenty-one patients completed the study. There was a significant decrease in the serum vitamin B12 level (601.84±398.43 to 363±337.31) post-chemotherapy among the control group. Among the prophylaxis group, the mean value of serum vitamin B12 increased significantly after chemotherapy. To summarize, there was a significant decrease in the amplitude of nerve conduction study in the control group as compared to the prophylaxis group espe- cially in left (11.85±6.84 to 8.14±5.36) and right (14.01±6.05 to 9.52±6.08) Sural nerves. Conclusions:Vitamin B12 injection had an important role in the prevention of development of chronic oxaliplatin-induced peripheral neuropathy. https://amj.khcms.edu.krd/index.php/main/article/view/242OxaliplatinOxaliplatin-induced peripheral neuropathyVitamin B12 |
| spellingShingle | Naza Shakir Shareef Shekhany Jangi Shawkat Salai Can Cobalamin prevent Oxaliplatin induced peripheral neuropathy? Advanced Medical Journal Oxaliplatin Oxaliplatin-induced peripheral neuropathy Vitamin B12 |
| title | Can Cobalamin prevent Oxaliplatin induced peripheral neuropathy? |
| title_full | Can Cobalamin prevent Oxaliplatin induced peripheral neuropathy? |
| title_fullStr | Can Cobalamin prevent Oxaliplatin induced peripheral neuropathy? |
| title_full_unstemmed | Can Cobalamin prevent Oxaliplatin induced peripheral neuropathy? |
| title_short | Can Cobalamin prevent Oxaliplatin induced peripheral neuropathy? |
| title_sort | can cobalamin prevent oxaliplatin induced peripheral neuropathy |
| topic | Oxaliplatin Oxaliplatin-induced peripheral neuropathy Vitamin B12 |
| url | https://amj.khcms.edu.krd/index.php/main/article/view/242 |
| work_keys_str_mv | AT nazashakirshareefshekhany cancobalaminpreventoxaliplatininducedperipheralneuropathy AT jangishawkatsalai cancobalaminpreventoxaliplatininducedperipheralneuropathy |