ROS-Mediated Unfolded Protein Response Activation Drives Hepatocyte Apoptosis in Mesaconitine-Induced Liver Injury

ROS-Mediated Unfolded Protein Response Activation Drives Hepatocyte Apoptosis in Mesaconitine-Induced Liver Injury

Mesaconitine (MA), a predominant diterpenoid alkaloid isolated from Aconitum species, exhibits notable pharmacological properties but is simultaneously associated with significant toxicological concerns, with its hepatotoxic mechanisms remaining largely unelucidated. In this study, zebrafish embryos...

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Bibliographic Details
Main Authors: Jin Tian, Yubin Zhuang, Yinuo Liu, Yihong Zheng, Xuyang Liu, Shiyu Lin, Chenhua Zheng, Zekai Wu
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Toxics
Subjects:
mesaconitine (MA)
hepatotoxicity
inflammation
oxidative stress
apoptosis
unfolded protein response (UPR)
Online Access:https://www.mdpi.com/2305-6304/13/3/155
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