γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies
Gamma delta (γδ) T-cell antigen receptor (TCR) expression and its related T-cell differentiation are not commonly reported in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL). Here we report two pediatric T-ALL cases and present their clinical features, histology, immunophenotypes, cytogenetics,...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/5873015 |
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| author | Eric X. Wei Vasiliki Leventaki John K. Choi Susana C. Raimondi Elizabeth M. Azzato Sheila A. Shurtleff Menchu G. Ong Diana M. Veillon James D. Cotelingam Rodney E. Shackelford |
| author_facet | Eric X. Wei Vasiliki Leventaki John K. Choi Susana C. Raimondi Elizabeth M. Azzato Sheila A. Shurtleff Menchu G. Ong Diana M. Veillon James D. Cotelingam Rodney E. Shackelford |
| author_sort | Eric X. Wei |
| collection | DOAJ |
| description | Gamma delta (γδ) T-cell antigen receptor (TCR) expression and its related T-cell differentiation are not commonly reported in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL). Here we report two pediatric T-ALL cases and present their clinical features, histology, immunophenotypes, cytogenetics, and molecular diagnostic findings. The first patient is a two-year-old girl with leukocytosis, circulating lymphoblasts, and a cryptic insertion of a short-arm segment at 10p12 into the long-arm segment of 11q23 resulting in an MLL and AF10 fusion transcript, which may be the first reported in γδ T-ALL. She responded to the chemotherapy protocol poorly and had persistent diseases. Following an allogeneic bone marrow transplant, she went into remission. The second patient is an eleven-year-old boy with a normal white cell count, circulating blasts, and a normal karyotype, but without any immature cellular markers by flow cytometric analysis. He responded to the chemotherapy well and achieved a complete remission. These cases demonstrate the diverse phenotypic, cytogenetic, and molecular aspects of γδ T-ALL. Early T-precursor- (ETP-) ALL and their differential diagnosis from other mature γδ T-cell leukemia/lymphomas are also discussed. |
| format | Article |
| id | doaj-art-81f1594caaf947f3b5fda567be040c4d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-81f1594caaf947f3b5fda567be040c4d2025-02-03T01:09:29ZengWileyCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/58730155873015γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell MalignanciesEric X. Wei0Vasiliki Leventaki1John K. Choi2Susana C. Raimondi3Elizabeth M. Azzato4Sheila A. Shurtleff5Menchu G. Ong6Diana M. Veillon7James D. Cotelingam8Rodney E. Shackelford9Department of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, USADepartment of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, USADepartment of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, USADepartment of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, USADepartment of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, USAGamma delta (γδ) T-cell antigen receptor (TCR) expression and its related T-cell differentiation are not commonly reported in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL). Here we report two pediatric T-ALL cases and present their clinical features, histology, immunophenotypes, cytogenetics, and molecular diagnostic findings. The first patient is a two-year-old girl with leukocytosis, circulating lymphoblasts, and a cryptic insertion of a short-arm segment at 10p12 into the long-arm segment of 11q23 resulting in an MLL and AF10 fusion transcript, which may be the first reported in γδ T-ALL. She responded to the chemotherapy protocol poorly and had persistent diseases. Following an allogeneic bone marrow transplant, she went into remission. The second patient is an eleven-year-old boy with a normal white cell count, circulating blasts, and a normal karyotype, but without any immature cellular markers by flow cytometric analysis. He responded to the chemotherapy well and achieved a complete remission. These cases demonstrate the diverse phenotypic, cytogenetic, and molecular aspects of γδ T-ALL. Early T-precursor- (ETP-) ALL and their differential diagnosis from other mature γδ T-cell leukemia/lymphomas are also discussed.http://dx.doi.org/10.1155/2017/5873015 |
| spellingShingle | Eric X. Wei Vasiliki Leventaki John K. Choi Susana C. Raimondi Elizabeth M. Azzato Sheila A. Shurtleff Menchu G. Ong Diana M. Veillon James D. Cotelingam Rodney E. Shackelford γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies Case Reports in Hematology |
| title | γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies |
| title_full | γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies |
| title_fullStr | γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies |
| title_full_unstemmed | γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies |
| title_short | γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies |
| title_sort | γδ t cell acute lymphoblastic leukemia lymphoma discussion of two pediatric cases and its distinction from other mature γδ t cell malignancies |
| url | http://dx.doi.org/10.1155/2017/5873015 |
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