The role of immunohistochemical evaluation in the diagnosis of malignant mesothelioma of the pleura
Backround/Aim. The final diagnosis of malignant pleural mesothelioma is made exclusively by histopathological examination of biopsy materials that are routinely complemented by the use of immunohistochemical analysis. The aim of this paper was to determine the significance of immunohistochemical...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2013-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501300025P.pdf |
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| author | Panjković Milana Lovrenski Aleksandra Eri Živka Knežević-Ušaj Slavica Tegeltija Dragana Krčedinac Jelena |
| author_facet | Panjković Milana Lovrenski Aleksandra Eri Živka Knežević-Ušaj Slavica Tegeltija Dragana Krčedinac Jelena |
| author_sort | Panjković Milana |
| collection | DOAJ |
| description | Backround/Aim. The final diagnosis of malignant pleural mesothelioma is made exclusively by histopathological examination of biopsy materials that are routinely complemented by the use of immunohistochemical analysis. The aim of this paper was to determine the significance of immunohistochemical analysis and application of certain antibodies in the diagnosis of malignant pleural mesothelioma. Methods. This retrospective analysis included clinical data of 32 patients with the histopathological diagnosis of malignant pleural mesothelioma made in the period 2004-2009 at the Institute for Pulmonary Diseases in Sremska Kamenica. The material was processed and analyzed at the Center for Pathology. Results. CK5/6 was positive, in 63% of the cases calretinin, in 94% and HBME-1 in 80% of the cases. CK7 was positive in 78%, and EMA in 83% of the cases. All the cases (100%) were negative for TTF-1, CEA, CD20, desmin and MOC31. Conclusion. Immunohistochemistry has become an essential diagnostic procedure for the diagnosis and determination of the type of malignant pleural mesothelioma, and due to the lack of individual antibodies a combination of antibody with different sensitivity and specificity is in use today. |
| format | Article |
| id | doaj-art-81ebb1733e4e44a7a70a459324af18bc |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-81ebb1733e4e44a7a70a459324af18bc2025-08-20T03:35:24ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502013-01-0170111010101410.2298/VSP110527025PThe role of immunohistochemical evaluation in the diagnosis of malignant mesothelioma of the pleuraPanjković MilanaLovrenski AleksandraEri ŽivkaKnežević-Ušaj SlavicaTegeltija DraganaKrčedinac JelenaBackround/Aim. The final diagnosis of malignant pleural mesothelioma is made exclusively by histopathological examination of biopsy materials that are routinely complemented by the use of immunohistochemical analysis. The aim of this paper was to determine the significance of immunohistochemical analysis and application of certain antibodies in the diagnosis of malignant pleural mesothelioma. Methods. This retrospective analysis included clinical data of 32 patients with the histopathological diagnosis of malignant pleural mesothelioma made in the period 2004-2009 at the Institute for Pulmonary Diseases in Sremska Kamenica. The material was processed and analyzed at the Center for Pathology. Results. CK5/6 was positive, in 63% of the cases calretinin, in 94% and HBME-1 in 80% of the cases. CK7 was positive in 78%, and EMA in 83% of the cases. All the cases (100%) were negative for TTF-1, CEA, CD20, desmin and MOC31. Conclusion. Immunohistochemistry has become an essential diagnostic procedure for the diagnosis and determination of the type of malignant pleural mesothelioma, and due to the lack of individual antibodies a combination of antibody with different sensitivity and specificity is in use today.http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501300025P.pdfplural neoplasmsmesotheliomaimmunohistochemistry |
| spellingShingle | Panjković Milana Lovrenski Aleksandra Eri Živka Knežević-Ušaj Slavica Tegeltija Dragana Krčedinac Jelena The role of immunohistochemical evaluation in the diagnosis of malignant mesothelioma of the pleura Vojnosanitetski Pregled plural neoplasms mesothelioma immunohistochemistry |
| title | The role of immunohistochemical evaluation in the diagnosis of malignant mesothelioma of the pleura |
| title_full | The role of immunohistochemical evaluation in the diagnosis of malignant mesothelioma of the pleura |
| title_fullStr | The role of immunohistochemical evaluation in the diagnosis of malignant mesothelioma of the pleura |
| title_full_unstemmed | The role of immunohistochemical evaluation in the diagnosis of malignant mesothelioma of the pleura |
| title_short | The role of immunohistochemical evaluation in the diagnosis of malignant mesothelioma of the pleura |
| title_sort | role of immunohistochemical evaluation in the diagnosis of malignant mesothelioma of the pleura |
| topic | plural neoplasms mesothelioma immunohistochemistry |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501300025P.pdf |
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