Ultrasonographic study of the thumb pulleys and their entheses: correlations with anatomy and histology

Objectives The entheseal nature of digital annular pulleys insertion was recently described, with high resolution ultrasound (US) reliably identifying these submillimetre structures with impressive accuracy. Since the thumb was not examined, the aim of the present study was to characterise the thumb...

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Main Authors: Ingrid Moller, Maria Antonietta D’Agostino, Joan Blasi, Chiara Rizzo, Luis Coronel, David A. Bong, Maribel Miguel-Pérez, Juan Angel Patiño Galindo
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/11/2/e005544.full
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author Ingrid Moller
Maria Antonietta D’Agostino
Joan Blasi
Chiara Rizzo
Luis Coronel
David A. Bong
Maribel Miguel-Pérez
Juan Angel Patiño Galindo
author_facet Ingrid Moller
Maria Antonietta D’Agostino
Joan Blasi
Chiara Rizzo
Luis Coronel
David A. Bong
Maribel Miguel-Pérez
Juan Angel Patiño Galindo
author_sort Ingrid Moller
collection DOAJ
description Objectives The entheseal nature of digital annular pulleys insertion was recently described, with high resolution ultrasound (US) reliably identifying these submillimetre structures with impressive accuracy. Since the thumb was not examined, the aim of the present study was to characterise the thumb annular pulley system, including entheses, from an anatomical, histological and ultrasonographic perspective.Methods US assessment and gross anatomical dissection were performed on cadaveric thumbs to investigate the thickness and structural features of the four thumb pulleys, including the identification of their entheses. US and anatomical measurements were correlated. Entheses identified by US were verified by histology. All thumb pulleys in healthy controls (HC) were detected and thickness was measured by US. A reliability exercise on US identification and anatomical study of thumb pulleys was carried out.Results 20 cadaveric thumbs and 40 thumbs from HC were examined. A total of 240 thumb pulleys (80 cadaveric, 160 HC) were analysed. The cadaveric study demonstrated good correlation between anatomical and US measurement of thumb pulleys thickness (r=0.8). Histology confirmed the entheseal nature of thumb pulleys insertions, with both fibrous and fibrocartilaginous features. 267/480 (55.6%) entheses were detected by US. A1 pulley entheses were always visualised while oblique pulley and A2 pulley entheses were seldom identified. The intrarater and inter-rater reliability showed good correlation among participants.Conclusions US is an effective and reliable tool to detect and study thumb pulleys, even though the identification of their entheses may be challenging and require advanced US skills.
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spelling doaj-art-81e8970dde344a17a78b96c95f9cc5742025-08-20T02:16:05ZengBMJ Publishing GroupRMD Open2056-59332025-04-0111210.1136/rmdopen-2025-005544Ultrasonographic study of the thumb pulleys and their entheses: correlations with anatomy and histologyIngrid Moller0Maria Antonietta D’Agostino1Joan Blasi2Chiara Rizzo3Luis Coronel4David A. Bong5Maribel Miguel-Pérez6Juan Angel Patiño Galindo7Instituto Poal de Reumatología, Barcelona, SpainRheumatology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, ItalyHistology Unit, Faculty of Medicine and Health Sciences (Campus de Bellvitge), University of Barcelona, Barcelona, SpainDepartment of Health Promotion, Mother and Childcare, Internal Medicine and Medical Specialties, Rheumatology Section, University of Palermo, Palermo, ItalyHospital Universitario Nuestra Señora de la Candelaria, Tenerife, SpainInstituto Poal de Reumatología, Barcelona, SpainUnit of Human Anatomy and Embryology, Department of Pathology and Experimental Therapeutics (Campus of Bellvitge), University of Barcelona, Barcelona, SpainIMIDomics, Inc, Barcelona, SpainObjectives The entheseal nature of digital annular pulleys insertion was recently described, with high resolution ultrasound (US) reliably identifying these submillimetre structures with impressive accuracy. Since the thumb was not examined, the aim of the present study was to characterise the thumb annular pulley system, including entheses, from an anatomical, histological and ultrasonographic perspective.Methods US assessment and gross anatomical dissection were performed on cadaveric thumbs to investigate the thickness and structural features of the four thumb pulleys, including the identification of their entheses. US and anatomical measurements were correlated. Entheses identified by US were verified by histology. All thumb pulleys in healthy controls (HC) were detected and thickness was measured by US. A reliability exercise on US identification and anatomical study of thumb pulleys was carried out.Results 20 cadaveric thumbs and 40 thumbs from HC were examined. A total of 240 thumb pulleys (80 cadaveric, 160 HC) were analysed. The cadaveric study demonstrated good correlation between anatomical and US measurement of thumb pulleys thickness (r=0.8). Histology confirmed the entheseal nature of thumb pulleys insertions, with both fibrous and fibrocartilaginous features. 267/480 (55.6%) entheses were detected by US. A1 pulley entheses were always visualised while oblique pulley and A2 pulley entheses were seldom identified. The intrarater and inter-rater reliability showed good correlation among participants.Conclusions US is an effective and reliable tool to detect and study thumb pulleys, even though the identification of their entheses may be challenging and require advanced US skills.https://rmdopen.bmj.com/content/11/2/e005544.full
spellingShingle Ingrid Moller
Maria Antonietta D’Agostino
Joan Blasi
Chiara Rizzo
Luis Coronel
David A. Bong
Maribel Miguel-Pérez
Juan Angel Patiño Galindo
Ultrasonographic study of the thumb pulleys and their entheses: correlations with anatomy and histology
RMD Open
title Ultrasonographic study of the thumb pulleys and their entheses: correlations with anatomy and histology
title_full Ultrasonographic study of the thumb pulleys and their entheses: correlations with anatomy and histology
title_fullStr Ultrasonographic study of the thumb pulleys and their entheses: correlations with anatomy and histology
title_full_unstemmed Ultrasonographic study of the thumb pulleys and their entheses: correlations with anatomy and histology
title_short Ultrasonographic study of the thumb pulleys and their entheses: correlations with anatomy and histology
title_sort ultrasonographic study of the thumb pulleys and their entheses correlations with anatomy and histology
url https://rmdopen.bmj.com/content/11/2/e005544.full
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