Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing
Effective wound repair is critically impaired by persistent inflammatory responses and oxidative damage, which collectively impede tissue regeneration and exacerbate fibrotic scarring. To overcome these dual barriers, we engineered a multifunctional hydrogel platform, designated KGM-GA/XG-DPA (KG-XD...
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KeAi Communications Co., Ltd.
2025-11-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25003160 |
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| author | Huiyang Li Lifei Ma Ni Zhu Xiaoyu Liang Kaijing Liu Xue Fu Chuangnian Zhang Jing Yang |
| author_facet | Huiyang Li Lifei Ma Ni Zhu Xiaoyu Liang Kaijing Liu Xue Fu Chuangnian Zhang Jing Yang |
| author_sort | Huiyang Li |
| collection | DOAJ |
| description | Effective wound repair is critically impaired by persistent inflammatory responses and oxidative damage, which collectively impede tissue regeneration and exacerbate fibrotic scarring. To overcome these dual barriers, we engineered a multifunctional hydrogel platform, designated KGM-GA/XG-DPA (KG-XDgel), through molecular integration of gallic acid-conjugated konjac glucomannan (KGM-GA) with dopamine-modified xanthan gum (XG-DPA). This biomaterial system demonstrates dual therapeutic modalities: (1) concurrent scavenging of reactive oxygen species (ROS) via synergistic redox activity from phenolic components (gallic acid and catechol moieties), and (2) targeted immunomodulation through carbohydrate-mediated engagement of CD206 receptors to drive M2 macrophage polarization. Enhanced by dopamine-driven tissue adhesion and self-healing properties, the hydrogel maintains structural integrity under physiological stress. In murine full-thickness wound models, KG-XDgel treatment achieved an impressive 81 % epithelial closure within 7 days, accompanied by an 8.7-fold upregulation of CD31+ neovascular networks by day 14. Notably, these therapeutic outcomes were accomplished through endogenous biological activation rather than exogenous growth factors or pharmacological agents. By converging antioxidant defense with innate immune reprogramming in a single biomaterial platform, KG-XDgel establishes a novel drug-free paradigm for accelerated wound regeneration, demonstrating significant translational potential in clinical wound management. |
| format | Article |
| id | doaj-art-81e3d379b07240608fafe5783f9d4c72 |
| institution | DOAJ |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-81e3d379b07240608fafe5783f9d4c722025-08-20T03:08:56ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-11-015350752110.1016/j.bioactmat.2025.07.023Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healingHuiyang Li0Lifei Ma1Ni Zhu2Xiaoyu Liang3Kaijing Liu4Xue Fu5Chuangnian Zhang6Jing Yang7State Key Laboratory of Advanced Medical Materials and Devices, Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device (Ministry of Education), Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300192, China; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47906, USADepartment of Biochemistry & Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, ChinaState Key Laboratory of Advanced Medical Materials and Devices, Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device (Ministry of Education), Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300192, ChinaState Key Laboratory of Advanced Medical Materials and Devices, Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device (Ministry of Education), Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300192, ChinaState Key Laboratory of Advanced Medical Materials and Devices, Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device (Ministry of Education), Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300192, ChinaState Key Laboratory of Advanced Medical Materials and Devices, Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device (Ministry of Education), Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300192, ChinaState Key Laboratory of Advanced Medical Materials and Devices, Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device (Ministry of Education), Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300192, China; Corresponding author.State Key Laboratory of Advanced Medical Materials and Devices, Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device (Ministry of Education), Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300192, China; Corresponding author.Effective wound repair is critically impaired by persistent inflammatory responses and oxidative damage, which collectively impede tissue regeneration and exacerbate fibrotic scarring. To overcome these dual barriers, we engineered a multifunctional hydrogel platform, designated KGM-GA/XG-DPA (KG-XDgel), through molecular integration of gallic acid-conjugated konjac glucomannan (KGM-GA) with dopamine-modified xanthan gum (XG-DPA). This biomaterial system demonstrates dual therapeutic modalities: (1) concurrent scavenging of reactive oxygen species (ROS) via synergistic redox activity from phenolic components (gallic acid and catechol moieties), and (2) targeted immunomodulation through carbohydrate-mediated engagement of CD206 receptors to drive M2 macrophage polarization. Enhanced by dopamine-driven tissue adhesion and self-healing properties, the hydrogel maintains structural integrity under physiological stress. In murine full-thickness wound models, KG-XDgel treatment achieved an impressive 81 % epithelial closure within 7 days, accompanied by an 8.7-fold upregulation of CD31+ neovascular networks by day 14. Notably, these therapeutic outcomes were accomplished through endogenous biological activation rather than exogenous growth factors or pharmacological agents. By converging antioxidant defense with innate immune reprogramming in a single biomaterial platform, KG-XDgel establishes a novel drug-free paradigm for accelerated wound regeneration, demonstrating significant translational potential in clinical wound management.http://www.sciencedirect.com/science/article/pii/S2452199X25003160HydrogelM2 macrophageROS scavengingNeovascularizationWound healing |
| spellingShingle | Huiyang Li Lifei Ma Ni Zhu Xiaoyu Liang Kaijing Liu Xue Fu Chuangnian Zhang Jing Yang Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing Bioactive Materials Hydrogel M2 macrophage ROS scavenging Neovascularization Wound healing |
| title | Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing |
| title_full | Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing |
| title_fullStr | Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing |
| title_full_unstemmed | Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing |
| title_short | Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing |
| title_sort | natural origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing |
| topic | Hydrogel M2 macrophage ROS scavenging Neovascularization Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25003160 |
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