Association between wide-ranging food intake and Parkinson’s disease: a comprehensive mendelian randomization study
Abstract Parkinson’s disease (PD) is a complex neurodegenerative disorder influenced by both genetic and environmental factors, including dietary habits. Despite considerable research, the relationship between food intake and PD risk remains poorly understood. Here, we conducted a comprehensive Mend...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-85668-x |
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| author | Yana Su Yulei Hao Wanhui Dong Ruqing Qiu Ying Zhang |
| author_facet | Yana Su Yulei Hao Wanhui Dong Ruqing Qiu Ying Zhang |
| author_sort | Yana Su |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is a complex neurodegenerative disorder influenced by both genetic and environmental factors, including dietary habits. Despite considerable research, the relationship between food intake and PD risk remains poorly understood. Here, we conducted a comprehensive Mendelian randomization analysis to investigate the association between a wide spectrum of food intake and PD risk. Utilizing data from large-scale genome-wide association studies (GWAS) and dietary databases, we constructed genetic instruments for various dietary factors, including fruit, vegetable, meat, fish, dairy, and grain intake, among others, totaling 170 different food items. Using multivariable inverse variance weighted methods, we found a causal relationship between Mozzarella intake and Parkinson’s disease (odds ratio [OR] = 9.83, 95% confidence interval [CI] = 2.52–38.34, P-value < 0.05). Additionally, a causal relationship was observed between Pancake intake and Parkinson’s disease (odds ratio [OR] = 0.20, 95% confidence interval [CI] = 0.07–0.59, P-value < 0.05). Furthermore, our reverse Mendelian randomization analysis and multivariable Mendelian randomization analysis provided further support for these findings. To our knowledge, we are the first to investigate the causal relationship between the broad intake of 170 different food items and Parkinson’s disease. Our study reveals the causal relationships between Pancake intake, and Mozzarella intake with Parkinson’s disease. |
| format | Article |
| id | doaj-art-81e002717aa34648a38d1ea05c7ce000 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-81e002717aa34648a38d1ea05c7ce0002025-01-19T12:22:42ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-025-85668-xAssociation between wide-ranging food intake and Parkinson’s disease: a comprehensive mendelian randomization studyYana Su0Yulei Hao1Wanhui Dong2Ruqing Qiu3Ying Zhang4Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin UniversityDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin UniversityDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin UniversityDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin UniversityDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin UniversityAbstract Parkinson’s disease (PD) is a complex neurodegenerative disorder influenced by both genetic and environmental factors, including dietary habits. Despite considerable research, the relationship between food intake and PD risk remains poorly understood. Here, we conducted a comprehensive Mendelian randomization analysis to investigate the association between a wide spectrum of food intake and PD risk. Utilizing data from large-scale genome-wide association studies (GWAS) and dietary databases, we constructed genetic instruments for various dietary factors, including fruit, vegetable, meat, fish, dairy, and grain intake, among others, totaling 170 different food items. Using multivariable inverse variance weighted methods, we found a causal relationship between Mozzarella intake and Parkinson’s disease (odds ratio [OR] = 9.83, 95% confidence interval [CI] = 2.52–38.34, P-value < 0.05). Additionally, a causal relationship was observed between Pancake intake and Parkinson’s disease (odds ratio [OR] = 0.20, 95% confidence interval [CI] = 0.07–0.59, P-value < 0.05). Furthermore, our reverse Mendelian randomization analysis and multivariable Mendelian randomization analysis provided further support for these findings. To our knowledge, we are the first to investigate the causal relationship between the broad intake of 170 different food items and Parkinson’s disease. Our study reveals the causal relationships between Pancake intake, and Mozzarella intake with Parkinson’s disease.https://doi.org/10.1038/s41598-025-85668-xParkinson’s diseaseFood intakeMendelian randomizationDietary habits |
| spellingShingle | Yana Su Yulei Hao Wanhui Dong Ruqing Qiu Ying Zhang Association between wide-ranging food intake and Parkinson’s disease: a comprehensive mendelian randomization study Scientific Reports Parkinson’s disease Food intake Mendelian randomization Dietary habits |
| title | Association between wide-ranging food intake and Parkinson’s disease: a comprehensive mendelian randomization study |
| title_full | Association between wide-ranging food intake and Parkinson’s disease: a comprehensive mendelian randomization study |
| title_fullStr | Association between wide-ranging food intake and Parkinson’s disease: a comprehensive mendelian randomization study |
| title_full_unstemmed | Association between wide-ranging food intake and Parkinson’s disease: a comprehensive mendelian randomization study |
| title_short | Association between wide-ranging food intake and Parkinson’s disease: a comprehensive mendelian randomization study |
| title_sort | association between wide ranging food intake and parkinson s disease a comprehensive mendelian randomization study |
| topic | Parkinson’s disease Food intake Mendelian randomization Dietary habits |
| url | https://doi.org/10.1038/s41598-025-85668-x |
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