MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways
Nanozymes with specific catalytic activity inhibit inflammation and promote wound healing efficiently and safely. In this work, multifunctional manganese-based nanozymes (MnGA) with antioxidant properties were successfully constructed via a simple coordination reaction in which manganese chloride wa...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004964 |
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| author | Xueting Guo Wenqi Wang Liting Lin Jie Shan Junyao Zhu Shipeng Ning Hanmei Li Xianwen Wang Decheng Lu |
| author_facet | Xueting Guo Wenqi Wang Liting Lin Jie Shan Junyao Zhu Shipeng Ning Hanmei Li Xianwen Wang Decheng Lu |
| author_sort | Xueting Guo |
| collection | DOAJ |
| description | Nanozymes with specific catalytic activity inhibit inflammation and promote wound healing efficiently and safely. In this work, multifunctional manganese-based nanozymes (MnGA) with antioxidant properties were successfully constructed via a simple coordination reaction in which manganese chloride was used as the manganese source and gallic acid (GA) was used as the ligand solution. MnGA possesses both catalase-like (CAT-like) and superoxide dismutase-like (SOD-like) activities and a reactive nitrogen species (RNS) scavenging capacity, which enables it to efficiently inhibit the inflammatory response. Specifically, MnGA scavenges superoxide anions and produces H2O2 via SOD-like activity and then consumes H2O2 to convert it to nontoxic H2O and O2 via CAT-like activity, resulting in a cascade of catalytic reactions to scavenge reactive oxygen species (ROS). Moreover, the scavenging of RNS by MnGA can amplify the anti-inflammatory effect in combination with the scavenging of ROS. RNA sequencing of mouse skin tissue further revealed that MnGA significantly reduces inflammation by modulating the nuclear factor kappa-B (NF-κB), Toll-like receptor (TLR), and NOD-like receptor (NLR) signaling pathways and promotes skin regeneration. In summary, MnGA nanocatalysts possess excellent antioxidative and anti-inflammatory properties, highlighting their potential applications in wound healing and inflammation treatment. |
| format | Article |
| id | doaj-art-81deb56a77fa4eb7a626fa7969791453 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-81deb56a77fa4eb7a626fa79697914532025-01-17T04:52:13ZengElsevierMaterials Today Bio2590-00642025-02-0130101435MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathwaysXueting Guo0Wenqi Wang1Liting Lin2Jie Shan3Junyao Zhu4Shipeng Ning5Hanmei Li6Xianwen Wang7Decheng Lu8School of Pharmacy, Anhui Medical University, Hefei, 230022, PR ChinaSchool of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, PR ChinaSchool of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, PR ChinaSchool of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, PR ChinaResearch Center of Nanomedicine Technology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, PR ChinaResearch Center of Nanomedicine Technology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, PR ChinaKey Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu, 610106, PR China; Corresponding author.lihanmei@cdu.edu.cnSchool of Pharmacy, Anhui Medical University, Hefei, 230022, PR China; School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, PR China; Corresponding author. School of Pharmacy, Anhui Medical University, Hefei, 230022, PR China.Research Center of Nanomedicine Technology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, PR China; Corresponding author.Nanozymes with specific catalytic activity inhibit inflammation and promote wound healing efficiently and safely. In this work, multifunctional manganese-based nanozymes (MnGA) with antioxidant properties were successfully constructed via a simple coordination reaction in which manganese chloride was used as the manganese source and gallic acid (GA) was used as the ligand solution. MnGA possesses both catalase-like (CAT-like) and superoxide dismutase-like (SOD-like) activities and a reactive nitrogen species (RNS) scavenging capacity, which enables it to efficiently inhibit the inflammatory response. Specifically, MnGA scavenges superoxide anions and produces H2O2 via SOD-like activity and then consumes H2O2 to convert it to nontoxic H2O and O2 via CAT-like activity, resulting in a cascade of catalytic reactions to scavenge reactive oxygen species (ROS). Moreover, the scavenging of RNS by MnGA can amplify the anti-inflammatory effect in combination with the scavenging of ROS. RNA sequencing of mouse skin tissue further revealed that MnGA significantly reduces inflammation by modulating the nuclear factor kappa-B (NF-κB), Toll-like receptor (TLR), and NOD-like receptor (NLR) signaling pathways and promotes skin regeneration. In summary, MnGA nanocatalysts possess excellent antioxidative and anti-inflammatory properties, highlighting their potential applications in wound healing and inflammation treatment.http://www.sciencedirect.com/science/article/pii/S2590006424004964MnGACatalase-likeSuperoxide dismutase-likeInflammatory response |
| spellingShingle | Xueting Guo Wenqi Wang Liting Lin Jie Shan Junyao Zhu Shipeng Ning Hanmei Li Xianwen Wang Decheng Lu MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways Materials Today Bio MnGA Catalase-like Superoxide dismutase-like Inflammatory response |
| title | MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways |
| title_full | MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways |
| title_fullStr | MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways |
| title_full_unstemmed | MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways |
| title_short | MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways |
| title_sort | mnga with multiple enzyme like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways |
| topic | MnGA Catalase-like Superoxide dismutase-like Inflammatory response |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004964 |
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