Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients
Background Systemic inflammation is associated with poor functional outcomes. However, the effects of improved inflammation on functional indicators remain unclear. This study aimed to clarify the relationship between improvements in systemic inflammation and activities of daily living in patients a...
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Korea Geriatrics Society
2024-12-01
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| Series: | Annals of Geriatric Medicine and Research |
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| Online Access: | http://www.e-agmr.org/upload/pdf/agmr-24-0020.pdf |
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| author | Kota Hori Yoshihiro Yoshimura Hidetaka Wakabayashi Fumihiko Nagano Ayaka Matsumoto Sayuri Shimazu Ai Shiraishi Yoshifumi Kido Takahiro Bise Aomi Kuzuhara Takenori Hamada Kouki Yoneda Kenichiro Maekawa |
| author_facet | Kota Hori Yoshihiro Yoshimura Hidetaka Wakabayashi Fumihiko Nagano Ayaka Matsumoto Sayuri Shimazu Ai Shiraishi Yoshifumi Kido Takahiro Bise Aomi Kuzuhara Takenori Hamada Kouki Yoneda Kenichiro Maekawa |
| author_sort | Kota Hori |
| collection | DOAJ |
| description | Background Systemic inflammation is associated with poor functional outcomes. However, the effects of improved inflammation on functional indicators remain unclear. This study aimed to clarify the relationship between improvements in systemic inflammation and activities of daily living in patients after stroke. Methods This retrospective cohort study included patients post stroke with systemic inflammation upon admission. Systemic inflammation was defined as a modified Glasgow Prognostic Score (mGPS) score of 1–2. Improvement in systemic inflammation was defined as a reduction in mGPS score or blood C-reactive protein (CRP) levels during hospitalization. The primary outcomes were the motor items of the Functional Independence Measure (FIM-motor) at discharge. We applied multiple linear regression analysis to examine whether reduced systemic inflammation was associated with outcomes after adjusting for confounding factors. Results Of the 1,490 patients recruited, 158 (median age of 79 years; 88 men) had systemic inflammation on admission and were included in the study. Among these patients, 131 (82.9%) and 147 (93.0%) exhibited reduced mGPS and CRP levels, respectively. The median change in CRP was 2.1 mg/dL (interquartile range, 1.1–3.8). Multivariate analysis revealed that improvements in mGPS (β=0.125, p=0.012) and CRP levels (β=0.108, p=0.108) were independently and positively associated with FIM-motor at discharge. Conclusions Improvement in systemic inflammation was positively associated with functional outcomes in patients post stroke. Early detection and therapeutic intervention for systemic inflammation may further improve outcomes in these patients. |
| format | Article |
| id | doaj-art-81dc52ea19fd437398d0d333cb4d22b0 |
| institution | Kabale University |
| issn | 2508-4798 2508-4909 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Korea Geriatrics Society |
| record_format | Article |
| series | Annals of Geriatric Medicine and Research |
| spelling | doaj-art-81dc52ea19fd437398d0d333cb4d22b02025-01-06T08:12:12ZengKorea Geriatrics SocietyAnnals of Geriatric Medicine and Research2508-47982508-49092024-12-0128438839410.4235/agmr.24.00201134Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke PatientsKota Hori0Yoshihiro Yoshimura1Hidetaka Wakabayashi2Fumihiko Nagano3Ayaka Matsumoto4Sayuri Shimazu5Ai Shiraishi6Yoshifumi Kido7Takahiro Bise8Aomi Kuzuhara9Takenori Hamada10Kouki Yoneda11Kenichiro Maekawa12 Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Department of Rehabilitation Medicine, Tokyo Women's Medical University Hospital, Tokyo, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan Center for Sarcopenia Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, JapanBackground Systemic inflammation is associated with poor functional outcomes. However, the effects of improved inflammation on functional indicators remain unclear. This study aimed to clarify the relationship between improvements in systemic inflammation and activities of daily living in patients after stroke. Methods This retrospective cohort study included patients post stroke with systemic inflammation upon admission. Systemic inflammation was defined as a modified Glasgow Prognostic Score (mGPS) score of 1–2. Improvement in systemic inflammation was defined as a reduction in mGPS score or blood C-reactive protein (CRP) levels during hospitalization. The primary outcomes were the motor items of the Functional Independence Measure (FIM-motor) at discharge. We applied multiple linear regression analysis to examine whether reduced systemic inflammation was associated with outcomes after adjusting for confounding factors. Results Of the 1,490 patients recruited, 158 (median age of 79 years; 88 men) had systemic inflammation on admission and were included in the study. Among these patients, 131 (82.9%) and 147 (93.0%) exhibited reduced mGPS and CRP levels, respectively. The median change in CRP was 2.1 mg/dL (interquartile range, 1.1–3.8). Multivariate analysis revealed that improvements in mGPS (β=0.125, p=0.012) and CRP levels (β=0.108, p=0.108) were independently and positively associated with FIM-motor at discharge. Conclusions Improvement in systemic inflammation was positively associated with functional outcomes in patients post stroke. Early detection and therapeutic intervention for systemic inflammation may further improve outcomes in these patients.http://www.e-agmr.org/upload/pdf/agmr-24-0020.pdfsystemic inflammationmodified glasgow prognostic scoreinflammation improvementsarcopeniafunctional outcomes |
| spellingShingle | Kota Hori Yoshihiro Yoshimura Hidetaka Wakabayashi Fumihiko Nagano Ayaka Matsumoto Sayuri Shimazu Ai Shiraishi Yoshifumi Kido Takahiro Bise Aomi Kuzuhara Takenori Hamada Kouki Yoneda Kenichiro Maekawa Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients Annals of Geriatric Medicine and Research systemic inflammation modified glasgow prognostic score inflammation improvement sarcopenia functional outcomes |
| title | Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients |
| title_full | Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients |
| title_fullStr | Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients |
| title_full_unstemmed | Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients |
| title_short | Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients |
| title_sort | improved systemic inflammation is associated with functional prognosis in post stroke patients |
| topic | systemic inflammation modified glasgow prognostic score inflammation improvement sarcopenia functional outcomes |
| url | http://www.e-agmr.org/upload/pdf/agmr-24-0020.pdf |
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