Advancements in the treatment of osteochondral lesions of the talus
Abstract Osteochondral lesions of the talus (OLT) are common ankle joint pathologies, often caused by traumatic or non-traumatic factors. Due to the anatomical characteristics and limited blood supply of the talus, the spontaneous healing capacity of OLT is poor, posing challenges for clinical treat...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-024-05314-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849220663084056576 |
|---|---|
| author | Lianjie Cheng Xuena Wang |
| author_facet | Lianjie Cheng Xuena Wang |
| author_sort | Lianjie Cheng |
| collection | DOAJ |
| description | Abstract Osteochondral lesions of the talus (OLT) are common ankle joint pathologies, often caused by traumatic or non-traumatic factors. Due to the anatomical characteristics and limited blood supply of the talus, the spontaneous healing capacity of OLT is poor, posing challenges for clinical treatment. Traditional treatments include conservative therapy and surgical interventions, but their efficacy is limited. In recent years, significant advancements in OLT treatment have been achieved with developments in biomaterials science, cell biology, and tissue engineering. This article summarizes the latest research progress in various treatment methods, including conservative treatment, bone marrow stimulation, chondrocyte transplantation, and osteochondral grafting, and evaluates the role of biological augmentation agents such as platelet-rich plasma (PRP) and concentrated bone marrow aspirate (CBMA) in promoting cartilage repair. Additionally, the application of biological scaffold technology offers new prospects for cartilage regeneration. Although emerging therapies show potential in clinical practice, further research is needed to evaluate their long-term efficacy, indications, and safety. This article aims to provide valuable references for clinicians, researchers, and policymakers, promoting the development and refinement of OLT treatment strategies. |
| format | Article |
| id | doaj-art-81d7e4d70caf48c1a064ce5fc8ce7f1d |
| institution | Kabale University |
| issn | 1749-799X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-81d7e4d70caf48c1a064ce5fc8ce7f1d2024-12-08T12:37:53ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2024-12-011911910.1186/s13018-024-05314-6Advancements in the treatment of osteochondral lesions of the talusLianjie Cheng0Xuena Wang1Department of Hand & Foot and Reconstructive Microsurgery, Shandong Provincial Hospital, Shandong First Medical UniversityDepartment of Nephropathy and Rheumatology, Shandong Provincial Third Hospital, Shandong UniversityAbstract Osteochondral lesions of the talus (OLT) are common ankle joint pathologies, often caused by traumatic or non-traumatic factors. Due to the anatomical characteristics and limited blood supply of the talus, the spontaneous healing capacity of OLT is poor, posing challenges for clinical treatment. Traditional treatments include conservative therapy and surgical interventions, but their efficacy is limited. In recent years, significant advancements in OLT treatment have been achieved with developments in biomaterials science, cell biology, and tissue engineering. This article summarizes the latest research progress in various treatment methods, including conservative treatment, bone marrow stimulation, chondrocyte transplantation, and osteochondral grafting, and evaluates the role of biological augmentation agents such as platelet-rich plasma (PRP) and concentrated bone marrow aspirate (CBMA) in promoting cartilage repair. Additionally, the application of biological scaffold technology offers new prospects for cartilage regeneration. Although emerging therapies show potential in clinical practice, further research is needed to evaluate their long-term efficacy, indications, and safety. This article aims to provide valuable references for clinicians, researchers, and policymakers, promoting the development and refinement of OLT treatment strategies.https://doi.org/10.1186/s13018-024-05314-6Osteochondral lesionsBone marrow stimulationChondrocyte transplantationOsteochondral graftingBiological augmentation agents |
| spellingShingle | Lianjie Cheng Xuena Wang Advancements in the treatment of osteochondral lesions of the talus Journal of Orthopaedic Surgery and Research Osteochondral lesions Bone marrow stimulation Chondrocyte transplantation Osteochondral grafting Biological augmentation agents |
| title | Advancements in the treatment of osteochondral lesions of the talus |
| title_full | Advancements in the treatment of osteochondral lesions of the talus |
| title_fullStr | Advancements in the treatment of osteochondral lesions of the talus |
| title_full_unstemmed | Advancements in the treatment of osteochondral lesions of the talus |
| title_short | Advancements in the treatment of osteochondral lesions of the talus |
| title_sort | advancements in the treatment of osteochondral lesions of the talus |
| topic | Osteochondral lesions Bone marrow stimulation Chondrocyte transplantation Osteochondral grafting Biological augmentation agents |
| url | https://doi.org/10.1186/s13018-024-05314-6 |
| work_keys_str_mv | AT lianjiecheng advancementsinthetreatmentofosteochondrallesionsofthetalus AT xuenawang advancementsinthetreatmentofosteochondrallesionsofthetalus |