Unexpected voriconazole toxicity due to nirmatrelvir/ritonavir: a case report on drug-drug interaction and the role of therapeutic drug monitoring

Unexpected voriconazole toxicity due to nirmatrelvir/ritonavir: a case report on drug-drug interaction and the role of therapeutic drug monitoring

Voriconazole is a triazole antifungal used for invasive fungal infections, particularly invasive aspergillosis. Its metabolism is primarily mediated by CYP2C19, with CYP3A4 and CYP2C9 also involved. Nirmatrelvir/ritonavir, an oral antiviral for COVID-19, inhibits CYP isoforms potentially altering th...

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Bibliographic Details
Main Authors: J. López-Hernández, A. B. Guisado-Gil, M. Mejías-Trueba, L. Herrera-Hidalgo, F. J. Reina-Martínez, M. V. Gil-Navarro
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
voriconazole
aspergillosis
COVID-19
drug-drug interactions
therapeutic drug monitoring
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1616061/full
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