The effect of Colchicine IN Sepsis (COLINS): a study protocol for a randomized, double-blind, placebo-controlled trial

The effect of Colchicine IN Sepsis (COLINS): a study protocol for a randomized, double-blind, placebo-controlled trial

Abstract Background Sepsis is a life-threatening condition with high mortality rates of up to 40% due to multiple organ dysfunction. Systemic inflammatory response plays a key role in the pathophysiology and progression of this disease. Therefore, anti-inflammatory drugs can be considered as augment...

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Bibliographic Details
Main Authors: Fariba Pourkarim, Ata Mahmoodpoor, Hassan Soleimanpour, Aliakbar Ghamari, Roghayeh Asghari-Ardabili, Parvin Sarbakhsh, Hadi Hamishehkar
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Trials
Subjects:
Sepsis
Colchicine
IL-6
COLINS
Anti-inflammatory
Clinical trial
Online Access:https://doi.org/10.1186/s13063-025-08901-y
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