Pyrrolidine, Piperazine, and Diazinane Alkaloids from the Marine Bacterium Strain <i>Vibrio ruber</i> ZXR-93
Four new alkaloids, vibripyrrolidine A (<b>1</b>), vibripiperazine A (<b>2</b>), and vibridiazinane A, B (<b>3</b>, <b>4</b>), comprising one pyrrolidine, one piperazine, and two diazinane alkaloids, along with two known analogs (<b>5</b>,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-09-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/29/18/4446 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Four new alkaloids, vibripyrrolidine A (<b>1</b>), vibripiperazine A (<b>2</b>), and vibridiazinane A, B (<b>3</b>, <b>4</b>), comprising one pyrrolidine, one piperazine, and two diazinane alkaloids, along with two known analogs (<b>5</b>, <b>6</b>), were isolated from the marine bacterium <i>Vibrio ruber</i> ZXR-93 cultured in ISP2 medium. Their chemical structures were elucidated by analysis of their 1D and 2D NMR, mass spectra, and electronic circular dichroism (ECD) calculations. Compounds <b>1</b> and <b>3</b>–<b>6</b> showed vigorous antibacterial activity against <i>Staphylococcus aureus</i>, with MIC values ranging from 0.96 to 7.81 μg/mL. Moreover, compound <b>1</b> exhibited robust anti-inflammatory activity in vitro using the LPS-induced RAW264.7 macrophage model. All compounds also showed moderate antineoplastic activity against cervical cancer cells (HeLa) and gastric cancer cells (SGC-7901). |
|---|---|
| ISSN: | 1420-3049 |