Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated wit...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2013/926395 |
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| author | Giuseppe Bersani Pietropaolo Marino Giuseppe Valeriani Valentina Cuoco Claudia Zitelli Claudia Melcore Francesco Saverio Bersani |
| author_facet | Giuseppe Bersani Pietropaolo Marino Giuseppe Valeriani Valentina Cuoco Claudia Zitelli Claudia Melcore Francesco Saverio Bersani |
| author_sort | Giuseppe Bersani |
| collection | DOAJ |
| description | Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended. |
| format | Article |
| id | doaj-art-81caf6560819419aba62966bb2ab4d75 |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-81caf6560819419aba62966bb2ab4d752025-02-03T05:44:07ZengWileyCase Reports in Psychiatry2090-682X2090-68382013-01-01201310.1155/2013/926395926395Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney TransplantGiuseppe Bersani0Pietropaolo Marino1Giuseppe Valeriani2Valentina Cuoco3Claudia Zitelli4Claudia Melcore5Francesco Saverio Bersani6Department of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalySeveral neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.http://dx.doi.org/10.1155/2013/926395 |
| spellingShingle | Giuseppe Bersani Pietropaolo Marino Giuseppe Valeriani Valentina Cuoco Claudia Zitelli Claudia Melcore Francesco Saverio Bersani Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant Case Reports in Psychiatry |
| title | Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant |
| title_full | Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant |
| title_fullStr | Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant |
| title_full_unstemmed | Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant |
| title_short | Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant |
| title_sort | manic like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant |
| url | http://dx.doi.org/10.1155/2013/926395 |
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