Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation
Vitamin B12 (cobalamin) is a water-soluble molecule required for the proper functioning of metabolism, blood and DNA synthesis, and neurological development. Vitamin B12 exists in several forms: methylcobalamin (MeCbl), adenosylcobalamin (AdoCbl), hydroxycobalamin (OHCbl), and cyanocobalamin (CNCbl)...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2024/8827402 |
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| author | Mazhar Salim Al Zoubi Mus’aab A. Al-Oun Fatima Yacoub Abusahyoun Manal Issam Abualarja Asmaa Al Smadi Bahaa Al-Trad Sura A. Awadin Khalid Al-Batayneh Mai Elaarag Raed M. Al-Zoubi |
| author_facet | Mazhar Salim Al Zoubi Mus’aab A. Al-Oun Fatima Yacoub Abusahyoun Manal Issam Abualarja Asmaa Al Smadi Bahaa Al-Trad Sura A. Awadin Khalid Al-Batayneh Mai Elaarag Raed M. Al-Zoubi |
| author_sort | Mazhar Salim Al Zoubi |
| collection | DOAJ |
| description | Vitamin B12 (cobalamin) is a water-soluble molecule required for the proper functioning of metabolism, blood and DNA synthesis, and neurological development. Vitamin B12 exists in several forms: methylcobalamin (MeCbl), adenosylcobalamin (AdoCbl), hydroxycobalamin (OHCbl), and cyanocobalamin (CNCbl). This study aimed to evaluate the effect of cigarette smoke on the chemical structure of methylcobalamin and hydroxycobalamin forms of vitamin B12. MeCbl and OHCbl were markedly affected by exposure to cigarette smoke. The resemblance of the Rt between MeCbl and OHCbl and CNCbl indicates that exposure to cigarette smoke extracts chemically alters MeCbl and OHCbl to CNCbl, warranting in vivo research investigations. |
| format | Article |
| id | doaj-art-81caef2d71c945a683cb50af65197547 |
| institution | Kabale University |
| issn | 2090-2255 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-81caef2d71c945a683cb50af651975472025-02-03T01:29:26ZengWileyBiochemistry Research International2090-22552024-01-01202410.1155/2024/8827402Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro EvaluationMazhar Salim Al Zoubi0Mus’aab A. Al-Oun1Fatima Yacoub Abusahyoun2Manal Issam Abualarja3Asmaa Al Smadi4Bahaa Al-Trad5Sura A. Awadin6Khalid Al-Batayneh7Mai Elaarag8Raed M. Al-Zoubi9Department of Basic Medical SciencesDepartment of Biological SciencesDepartment of Biological SciencesDepartment of Basic Medical SciencesDepartment of Biological SciencesDepartment of Biological SciencesDepartment of Biological SciencesDepartment of Biological SciencesSurgical Research SectionSurgical Research SectionVitamin B12 (cobalamin) is a water-soluble molecule required for the proper functioning of metabolism, blood and DNA synthesis, and neurological development. Vitamin B12 exists in several forms: methylcobalamin (MeCbl), adenosylcobalamin (AdoCbl), hydroxycobalamin (OHCbl), and cyanocobalamin (CNCbl). This study aimed to evaluate the effect of cigarette smoke on the chemical structure of methylcobalamin and hydroxycobalamin forms of vitamin B12. MeCbl and OHCbl were markedly affected by exposure to cigarette smoke. The resemblance of the Rt between MeCbl and OHCbl and CNCbl indicates that exposure to cigarette smoke extracts chemically alters MeCbl and OHCbl to CNCbl, warranting in vivo research investigations.http://dx.doi.org/10.1155/2024/8827402 |
| spellingShingle | Mazhar Salim Al Zoubi Mus’aab A. Al-Oun Fatima Yacoub Abusahyoun Manal Issam Abualarja Asmaa Al Smadi Bahaa Al-Trad Sura A. Awadin Khalid Al-Batayneh Mai Elaarag Raed M. Al-Zoubi Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation Biochemistry Research International |
| title | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation |
| title_full | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation |
| title_fullStr | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation |
| title_full_unstemmed | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation |
| title_short | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation |
| title_sort | exploring the impact of cigarette smoke extracts on vitamin b12 insights into the transformation of methylcobalamin and hydroxycobalamin to cyanocobalamin through in vitro evaluation |
| url | http://dx.doi.org/10.1155/2024/8827402 |
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