Low-Malignant Schwannoma of the Cervix in Pregnancy: A Case Report and Literature Systematic Review
Primary cervical melanocytic schwannomas, arising from the sympathetic chain, are very rare pigmented neural sheath tumors that, both grossly and clinically, are often misdiagnosed with other more frequent lesions of the uterine cervix. Literature review accounts for seventeen published cases of sch...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2021/6806960 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850213742375075840 |
|---|---|
| author | Giada M. ALMIRANTE Francesco CANTATORE Gianluca TACCAGNI Massimo CANDIANI Massimo ORIGONI |
| author_facet | Giada M. ALMIRANTE Francesco CANTATORE Gianluca TACCAGNI Massimo CANDIANI Massimo ORIGONI |
| author_sort | Giada M. ALMIRANTE |
| collection | DOAJ |
| description | Primary cervical melanocytic schwannomas, arising from the sympathetic chain, are very rare pigmented neural sheath tumors that, both grossly and clinically, are often misdiagnosed with other more frequent lesions of the uterine cervix. Literature review accounts for seventeen published cases of schwannomas of the cervix, ten of which are malignant and seven benign. Pathological examination with immunostaining techniques is essential for the correct diagnosis of these tumors. We report a case of primary cervical schwannoma in a 32-year-old female who was referred to our department at 13 weeks of gestation with a diagnosis of malignant melanoma of the cervix. Pathological review detailed a neoplasm with a myxoid spindle cell component and a minority of small epithelioid cells, with a low-malignant potential proliferation index: morphological and immunocytochemical findings were compatible with the diagnosis of nerve sheath tumor, type schwannoma. The patient underwent a vaginal trachelectomy and a prophylactic Shirodkar’s cerclage. Pregnancy was carried on without any negative event. The patient delivered by a caesarean section a healthy female newborn. Placental histology was negative. After 6 years from the first diagnosis, the patient is healthy and disease free. |
| format | Article |
| id | doaj-art-81ca2f4d6e74486d81dbf670f82dc427 |
| institution | OA Journals |
| issn | 2090-6692 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-81ca2f4d6e74486d81dbf670f82dc4272025-08-20T02:09:05ZengWileyCase Reports in Obstetrics and Gynecology2090-66922021-01-01202110.1155/2021/6806960Low-Malignant Schwannoma of the Cervix in Pregnancy: A Case Report and Literature Systematic ReviewGiada M. ALMIRANTE0Francesco CANTATORE1Gianluca TACCAGNI2Massimo CANDIANI3Massimo ORIGONI4Department of Obstetrics & GynaecologyDepartment of Obstetrics & GynaecologyDepartment of PathologyDepartment of Obstetrics & GynaecologyDepartment of Obstetrics & GynaecologyPrimary cervical melanocytic schwannomas, arising from the sympathetic chain, are very rare pigmented neural sheath tumors that, both grossly and clinically, are often misdiagnosed with other more frequent lesions of the uterine cervix. Literature review accounts for seventeen published cases of schwannomas of the cervix, ten of which are malignant and seven benign. Pathological examination with immunostaining techniques is essential for the correct diagnosis of these tumors. We report a case of primary cervical schwannoma in a 32-year-old female who was referred to our department at 13 weeks of gestation with a diagnosis of malignant melanoma of the cervix. Pathological review detailed a neoplasm with a myxoid spindle cell component and a minority of small epithelioid cells, with a low-malignant potential proliferation index: morphological and immunocytochemical findings were compatible with the diagnosis of nerve sheath tumor, type schwannoma. The patient underwent a vaginal trachelectomy and a prophylactic Shirodkar’s cerclage. Pregnancy was carried on without any negative event. The patient delivered by a caesarean section a healthy female newborn. Placental histology was negative. After 6 years from the first diagnosis, the patient is healthy and disease free.http://dx.doi.org/10.1155/2021/6806960 |
| spellingShingle | Giada M. ALMIRANTE Francesco CANTATORE Gianluca TACCAGNI Massimo CANDIANI Massimo ORIGONI Low-Malignant Schwannoma of the Cervix in Pregnancy: A Case Report and Literature Systematic Review Case Reports in Obstetrics and Gynecology |
| title | Low-Malignant Schwannoma of the Cervix in Pregnancy: A Case Report and Literature Systematic Review |
| title_full | Low-Malignant Schwannoma of the Cervix in Pregnancy: A Case Report and Literature Systematic Review |
| title_fullStr | Low-Malignant Schwannoma of the Cervix in Pregnancy: A Case Report and Literature Systematic Review |
| title_full_unstemmed | Low-Malignant Schwannoma of the Cervix in Pregnancy: A Case Report and Literature Systematic Review |
| title_short | Low-Malignant Schwannoma of the Cervix in Pregnancy: A Case Report and Literature Systematic Review |
| title_sort | low malignant schwannoma of the cervix in pregnancy a case report and literature systematic review |
| url | http://dx.doi.org/10.1155/2021/6806960 |
| work_keys_str_mv | AT giadamalmirante lowmalignantschwannomaofthecervixinpregnancyacasereportandliteraturesystematicreview AT francescocantatore lowmalignantschwannomaofthecervixinpregnancyacasereportandliteraturesystematicreview AT gianlucataccagni lowmalignantschwannomaofthecervixinpregnancyacasereportandliteraturesystematicreview AT massimocandiani lowmalignantschwannomaofthecervixinpregnancyacasereportandliteraturesystematicreview AT massimoorigoni lowmalignantschwannomaofthecervixinpregnancyacasereportandliteraturesystematicreview |