Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury

Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury

Background/Objectives: Nerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in individuals living with tetraplegia, significantly impacting daily life. While nearly a third of all individuals with chronic spinal cord injury may benefit from this interventio...

Full description

Saved in:

Bibliographic Details
Main Authors:	Juan Sebastián Jara, Marwa A. Soliman, Amanda Bernstein, Paola di Grazia, Adam R. Ferguson, Justin M. Brown, Abel Torres-Espín, Edmund R. Hollis
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Series:	Brain Sciences
Subjects:	chronic spinal cord injury tetraplegia nerve transfer surgery mouse model recovery regeneration
Online Access:	https://www.mdpi.com/2076-3425/15/3/251
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Systematic literature review related to the theoretical knowledge base for non-invasive monitoring of the biomechanical and visco-elastic properties of the myotendinous complex in patients with complete tetraplegia following cervical spinal cord injury
by: Ana-Andreea Cristea, et al.
Published: (2025-03-01)

Trunk kinematics during seated functional activities in individuals with spinal cord injury: a systematic review and meta-analysis
by: Maria del Rocio Hidalgo Mas, et al.
Published: (2025-07-01)

Exercise Core Body Temperature is Adequately Regulated Following Spinal Cord Injury: A Meta-Analysis
by: Yang Zhang, et al.
Published: (2019-10-01)

Assessment of Cardiac Autonomic Function by Short-Term Sensor-Based and Long-Term Heart Rate Variability Analyses in Individuals with Spinal Cord Injury After Long-Term Table Tennis Training
by: Georgia Vogiatzi, et al.
Published: (2024-11-01)

Mild intermittent hypoxia may improve autonomic dysfunction in persons living with spinal cord injury: a preliminary snapshot
by: Alexandra E. Soltesz, et al.
Published: (2025-07-01)

Respostas cardiovasculares e avaliação da potência aeróbia em pessoas com lesão da medula espinhal
by: Lucinar Flores, et al.
Published: (2013-08-01)

Development of machine learning models for gait-based classification of incomplete spinal cord injuries and cauda equina syndrome
by: Seul Gi Park, et al.
Published: (2025-06-01)

Morphometric analysis of peripheral nerves in people with spinal cord injury
by: Aurora Messina, et al.
Published: (2025-07-01)

Electrical stimulation of the sciatic nerve restores inspiratory diaphragm function in mice after spinal cord injury
by: Ian Walling, et al.
Published: (2025-01-01)

Spinal cord stimulation for spinal cord injury patients with paralysis: To regain walking and dignity
by: Sheng-Tzung Tsai, et al.
Published: (2021-01-01)

Degeneration of spinal ganglion and segmental apparatus of the spinal neurons in sciatic nerve injury: an experimental study
by: Vladimir S. Tolkachev, et al.
Published: (2021-12-01)

Extracellular vesicle-derived MicroRNAs as potential therapies for spinal cord and peripheral nerve injuries
by: Young-Ju Lim, et al.
Published: (2025-12-01)

Enhancing Neuroplasticity via vagus nerve stimulation to improve urinary dysfunction after spinal cord injury: a perspective
by: Mia J. Sargusingh, et al.
Published: (2025-06-01)

Potential benefits of spinal cord stimulation treatment on quality of life for paralyzed patients with spinal cord injury
by: Xiang-Ling Huang, et al.
Published: (2023-01-01)

Improved Motor Function in Cervical Spinal Cord Injury Following Spinal Cord Stimulation
by: Michael Suarez, et al.
Published: (2025-02-01)

Commentary: Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model
by: Yubin Peng, et al.
Published: (2025-07-01)

Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative review
by: Rodrigo Lantyer Marques Dantas, et al.
Published: (2024-12-01)

Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway
by: Ya Zheng, et al.
Published: (2025-12-01)

Spinal cord ischemia – from diagnosis to treatment
by: Małgorzata Wiszniewska, et al.
Published: (2024-07-01)

The Functioning of Patients with the Spinal Cord Stimulator
by: Małgorzata Kołpa, et al.
Published: (2016-06-01)

Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway in spinal cord injury
by: Yonghui Hou, et al.
Published: (2025-04-01)

Paralyzing paradox: Spinal cord infarction, a hidden emergency
by: Khurram Khaliq Bhinder, et al.
Published: (2025-04-01)

Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway
by: Yachen Wang, et al.
Published: (2024-04-01)

Spinal Cord Stimulation for Spinal Cord Injury-Related Pain: A Pilot Study
by: Alexander Alamri, et al.
Published: (2024-11-01)

Temporal changes of spinal microglia in murine models of neuropathic pain: a scoping review
by: Simran Dhir, et al.
Published: (2024-12-01)

Tethered Spinal Cords
by: J Gordon Millichap
Published: (1989-06-01)

Commentary: Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway in spinal cord injury
by: Yi Chen, et al.
Published: (2025-06-01)

Evolution of Spinal Cord Swelling in Acute Traumatic Spinal Cord Injury
by: Hasan Asif, et al.
Published: (2025-01-01)

A Fully Implantable and Programmable Epidural Spinal Cord Stimulation System for Rats With Spinal Cord Injury
by: Guangwei Mao, et al.
Published: (2023-01-01)

A Community Effort to Develop Common Data Elements for Pre-Clinical Spinal Cord Injury Research
by: Britt A. Fedor, et al.
Published: (2025-01-01)

Effect of epidural spinal cord stimulation in individuals with sensorimotor complete spinal cord injury: a pilot study
by: Vojtech Rybka, et al.
Published: (2025-07-01)

Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine
by: Joan Castellsagué, et al.
Published: (2015-03-01)

Cervicomedullary Spinal Cord Injury
by: Noah King, et al.
Published: (2025-02-01)

The Potential Roles of Astrocytes and Microglia in the Spinal Cord and Brain After Spinal Cord Injury
by: Fernando da Silva Fiorin, et al.
Published: (2025-03-01)

Imatinib prevents blood-spinal cord barrier disruption by inhibiting PDGFR-mediated JMJD3 expression and activation after spinal cord injury
by: Chan Sol Park, et al.
Published: (2025-07-01)

A Community Effort to Develop Common Data Elements for Pre-Clinical Spinal Cord Injury Research
by: Britt A. Fedor, et al.
Published: (2025-04-01)

Neuromodulation in Spinal Cord Injury Using Transcutaneous Spinal Stimulation—Mapping for a Blood Pressure Response: A Case Series
by: Einat Engel-Haber, et al.
Published: (2024-11-01)

Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration
by: Zhaoyang Gong, et al.
Published: (2025-01-01)

Reviews on pressure ulcers in bearers of spinal cord injury
by: Juliana Neves da Costa, et al.
Published: (2003-02-01)

Spine and Spinal Cord Injuries on the Basis of Medical Documentation
by: Joanna Rosińczuk, et al.
Published: (2014-06-01)