Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury
Background/Objectives: Nerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in individuals living with tetraplegia, significantly impacting daily life. While nearly a third of all individuals with chronic spinal cord injury may benefit from this interventio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/15/3/251 |
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| author | Juan Sebastián Jara Marwa A. Soliman Amanda Bernstein Paola di Grazia Adam R. Ferguson Justin M. Brown Abel Torres-Espín Edmund R. Hollis |
| author_facet | Juan Sebastián Jara Marwa A. Soliman Amanda Bernstein Paola di Grazia Adam R. Ferguson Justin M. Brown Abel Torres-Espín Edmund R. Hollis |
| author_sort | Juan Sebastián Jara |
| collection | DOAJ |
| description | Background/Objectives: Nerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in individuals living with tetraplegia, significantly impacting daily life. While nearly a third of all individuals with chronic spinal cord injury may benefit from this intervention, variability in outcomes can limit the functional impact. A bedside to bench approach was taken to address the variable response of tetraplegic individuals to nerve transfer surgery. Methods: We used a hierarchical multiple factor analysis to evaluate the effects of conditioning electrical stimulation (CES) on outcomes in a mouse model of nerve transfer to treat chronic cervical spinal cord injury. Results: We found that CES of donor nerves one week prior to nerve transfer surgery enhanced anatomical and functional measures of innervation of targeted muscles. Furthermore, CES increased the rate of recovery of naturalistic behavior. Conclusions: While the model has some limitations due to the small size of the rodent, our results support the use of CES as an effective approach to improve outcomes in clinical nerve repair settings. |
| format | Article |
| id | doaj-art-81c583a887bf44fcbe57f34e2af2ae27 |
| institution | DOAJ |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-81c583a887bf44fcbe57f34e2af2ae272025-08-20T02:42:42ZengMDPI AGBrain Sciences2076-34252025-02-0115325110.3390/brainsci15030251Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord InjuryJuan Sebastián Jara0Marwa A. Soliman1Amanda Bernstein2Paola di Grazia3Adam R. Ferguson4Justin M. Brown5Abel Torres-Espín6Edmund R. Hollis7Burke Neurological Institute, White Plains, NY 10605, USABurke Neurological Institute, White Plains, NY 10605, USABurke Neurological Institute, White Plains, NY 10605, USABurke Neurological Institute, White Plains, NY 10605, USABrain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, CA 94110, USAMassachusetts General Paralysis Center, Massachusetts General Hospital, Boston, MA 02114, USABrain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, CA 94110, USABurke Neurological Institute, White Plains, NY 10605, USABackground/Objectives: Nerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in individuals living with tetraplegia, significantly impacting daily life. While nearly a third of all individuals with chronic spinal cord injury may benefit from this intervention, variability in outcomes can limit the functional impact. A bedside to bench approach was taken to address the variable response of tetraplegic individuals to nerve transfer surgery. Methods: We used a hierarchical multiple factor analysis to evaluate the effects of conditioning electrical stimulation (CES) on outcomes in a mouse model of nerve transfer to treat chronic cervical spinal cord injury. Results: We found that CES of donor nerves one week prior to nerve transfer surgery enhanced anatomical and functional measures of innervation of targeted muscles. Furthermore, CES increased the rate of recovery of naturalistic behavior. Conclusions: While the model has some limitations due to the small size of the rodent, our results support the use of CES as an effective approach to improve outcomes in clinical nerve repair settings.https://www.mdpi.com/2076-3425/15/3/251chronic spinal cord injurytetraplegianerve transfer surgerymouse modelrecoveryregeneration |
| spellingShingle | Juan Sebastián Jara Marwa A. Soliman Amanda Bernstein Paola di Grazia Adam R. Ferguson Justin M. Brown Abel Torres-Espín Edmund R. Hollis Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury Brain Sciences chronic spinal cord injury tetraplegia nerve transfer surgery mouse model recovery regeneration |
| title | Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury |
| title_full | Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury |
| title_fullStr | Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury |
| title_full_unstemmed | Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury |
| title_short | Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury |
| title_sort | conditioning electrical nerve stimulation enhances functional rewiring in a mouse model of nerve transfer to treat chronic spinal cord injury |
| topic | chronic spinal cord injury tetraplegia nerve transfer surgery mouse model recovery regeneration |
| url | https://www.mdpi.com/2076-3425/15/3/251 |
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