The Link Between Gut Microbiota and Depression: Exploring the Correlation
Introduction: Depression represents a significant global health challenge, affecting approximately 4.4% of the global population and ranking as the leading cause of disability worldwide. Despite advancements in pharmacotherapy and psychotherapeutic interventions, a substantial proportion of indiv...
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| Format: | Article |
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Kazimierz Wielki University
2025-02-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/55276 |
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| author | Adam Juśkiewicz Olga Grelewicz Natalia Kucy Elwira Servaas Mateusz Haber Paula Kula Adrianna Czachor Alicja Kotula |
| author_facet | Adam Juśkiewicz Olga Grelewicz Natalia Kucy Elwira Servaas Mateusz Haber Paula Kula Adrianna Czachor Alicja Kotula |
| author_sort | Adam Juśkiewicz |
| collection | DOAJ |
| description |
Introduction: Depression represents a significant global health challenge, affecting approximately 4.4% of the global population and ranking as the leading cause of disability worldwide. Despite advancements in pharmacotherapy and psychotherapeutic interventions, a substantial proportion of individuals with depression experience treatment resistance, recurrence of symptoms, or inadequate response to standard treatments.
Aim of the Study: This review explores the emerging role of the gut microbiome in depression, focusing on its potential as a therapeutic target.
Materials and Methods: A comprehensive literature search was conducted using electronic databases including PubMed/MEDLINE and Google Scholar. The search encompassed articles utilizing keywords and Medical Subject Headings (MeSH) terms related to “gut microbiome,” “depression,” “microbiota-gut-brain axis,” “psychiatric disorders,” and “clinical studies.”
Conclusion: Therapeutic strategies targeting the gut microbiota offer promising avenues for alleviating depressive symptoms and enhancing treatment outcomes. Probiotics, prebiotics, dietary modifications, and fecal microbiota transplantation (FMT) represent diverse interventions aimed at restoring microbial balance, modulating gut-brain communication, and reducing neuroinflammation associated with depression. Further research is needed to optimize therapeutic approaches, explore personalized medicine strategies based on individual microbiome profiles and clarify the safety and efficacy of microbial-based therapies in clinical settings.
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| format | Article |
| id | doaj-art-81c05d7fcc074261b467027645271220 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-81c05d7fcc074261b4670276452712202025-02-04T08:17:34ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-02-017710.12775/JEHS.2025.77.55276The Link Between Gut Microbiota and Depression: Exploring the CorrelationAdam Juśkiewicz0https://orcid.org/0000-0001-9884-3513Olga Grelewicz1https://orcid.org/0000-0001-5738-9262Natalia Kucy2https://orcid.org/0009-0007-5468-6289Elwira Servaas3https://orcid.org/0009-0004-8432-7824Mateusz Haber4https://orcid.org/0009-0002-8441-4931Paula Kula5https://orcid.org/0009-0004-7503-2602Adrianna Czachor6https://orcid.org/0009-0001-8596-9341Alicja Kotula 7https://orcid.org/0009-0008-9718-1667National Medical Institute of the Ministry of the Interior and Administration, Wołoska 137, 02-507 WarszawaNational Medical Institute of the Ministry of the Interior and Administration, Wołoska 137, 02-507 WarszawaInfant Jesus Clinical Hospital UCC MUW, Lindleya 4, 02-005 Warszawa National Medical Institute of the Ministry of the Interior and Administration, Wołoska 137, 02-507 WarszawaCentral Clinical Hospital in Warsaw Banacha 1a, 02-097, WarszawaCentral Clinical Hospital in Warsaw, Banacha 1a, 02-097, WarszawaInfant Jesus Clinical Hospital UCC MUW, Lindleya 4, 02-005 Warszawa Infant Jesus Clinical Hospital UCC MUW, Lindleya 4, 02-005 Warszawa Introduction: Depression represents a significant global health challenge, affecting approximately 4.4% of the global population and ranking as the leading cause of disability worldwide. Despite advancements in pharmacotherapy and psychotherapeutic interventions, a substantial proportion of individuals with depression experience treatment resistance, recurrence of symptoms, or inadequate response to standard treatments. Aim of the Study: This review explores the emerging role of the gut microbiome in depression, focusing on its potential as a therapeutic target. Materials and Methods: A comprehensive literature search was conducted using electronic databases including PubMed/MEDLINE and Google Scholar. The search encompassed articles utilizing keywords and Medical Subject Headings (MeSH) terms related to “gut microbiome,” “depression,” “microbiota-gut-brain axis,” “psychiatric disorders,” and “clinical studies.” Conclusion: Therapeutic strategies targeting the gut microbiota offer promising avenues for alleviating depressive symptoms and enhancing treatment outcomes. Probiotics, prebiotics, dietary modifications, and fecal microbiota transplantation (FMT) represent diverse interventions aimed at restoring microbial balance, modulating gut-brain communication, and reducing neuroinflammation associated with depression. Further research is needed to optimize therapeutic approaches, explore personalized medicine strategies based on individual microbiome profiles and clarify the safety and efficacy of microbial-based therapies in clinical settings. https://apcz.umk.pl/JEHS/article/view/55276Gut microbiomeDepressionMicrobiota-gut-brain axisPsychiatric disordersProbioticsFecal microbiota transplantation (FMT) |
| spellingShingle | Adam Juśkiewicz Olga Grelewicz Natalia Kucy Elwira Servaas Mateusz Haber Paula Kula Adrianna Czachor Alicja Kotula The Link Between Gut Microbiota and Depression: Exploring the Correlation Journal of Education, Health and Sport Gut microbiome Depression Microbiota-gut-brain axis Psychiatric disorders Probiotics Fecal microbiota transplantation (FMT) |
| title | The Link Between Gut Microbiota and Depression: Exploring the Correlation |
| title_full | The Link Between Gut Microbiota and Depression: Exploring the Correlation |
| title_fullStr | The Link Between Gut Microbiota and Depression: Exploring the Correlation |
| title_full_unstemmed | The Link Between Gut Microbiota and Depression: Exploring the Correlation |
| title_short | The Link Between Gut Microbiota and Depression: Exploring the Correlation |
| title_sort | link between gut microbiota and depression exploring the correlation |
| topic | Gut microbiome Depression Microbiota-gut-brain axis Psychiatric disorders Probiotics Fecal microbiota transplantation (FMT) |
| url | https://apcz.umk.pl/JEHS/article/view/55276 |
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