Harnessing ferroptosis for precision oncology: challenges and prospects
Abstract The discovery of diverse molecular mechanisms of regulated cell death has opened new avenues for cancer therapy. Ferroptosis, a unique form of cell death driven by iron-catalyzed peroxidation of membrane phospholipids, holds particular promise for targeting resistant cancer types. This revi...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | BMC Biology |
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| Online Access: | https://doi.org/10.1186/s12915-025-02154-6 |
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| author | Roberto Fernández-Acosta Iuliana Vintea Ine Koeken Behrouz Hassannia Tom Vanden Berghe |
| author_facet | Roberto Fernández-Acosta Iuliana Vintea Ine Koeken Behrouz Hassannia Tom Vanden Berghe |
| author_sort | Roberto Fernández-Acosta |
| collection | DOAJ |
| description | Abstract The discovery of diverse molecular mechanisms of regulated cell death has opened new avenues for cancer therapy. Ferroptosis, a unique form of cell death driven by iron-catalyzed peroxidation of membrane phospholipids, holds particular promise for targeting resistant cancer types. This review critically examines current literature on ferroptosis, focusing on its defining features and therapeutic potential. We discuss how molecular profiling of tumors and liquid biopsies can generate extensive multi-omics datasets, which can be leveraged through machine learning-based analytical approaches for patient stratification. Addressing these challenges is essential for advancing the clinical integration of ferroptosis-driven treatments in cancer care. |
| format | Article |
| id | doaj-art-81be816b1adc4951bfac077ef142ec2b |
| institution | OA Journals |
| issn | 1741-7007 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj-art-81be816b1adc4951bfac077ef142ec2b2025-08-20T02:01:39ZengBMCBMC Biology1741-70072025-02-0123111710.1186/s12915-025-02154-6Harnessing ferroptosis for precision oncology: challenges and prospectsRoberto Fernández-Acosta0Iuliana Vintea1Ine Koeken2Behrouz Hassannia3Tom Vanden Berghe4Cell Death Signaling lab, Infla-Med Centre of Excellence, Department of Biomedical Sciences, University of AntwerpCell Death Signaling lab, Infla-Med Centre of Excellence, Department of Biomedical Sciences, University of AntwerpCell Death Signaling lab, Infla-Med Centre of Excellence, Department of Biomedical Sciences, University of AntwerpCell Death Signaling lab, Infla-Med Centre of Excellence, Department of Biomedical Sciences, University of AntwerpCell Death Signaling lab, Infla-Med Centre of Excellence, Department of Biomedical Sciences, University of AntwerpAbstract The discovery of diverse molecular mechanisms of regulated cell death has opened new avenues for cancer therapy. Ferroptosis, a unique form of cell death driven by iron-catalyzed peroxidation of membrane phospholipids, holds particular promise for targeting resistant cancer types. This review critically examines current literature on ferroptosis, focusing on its defining features and therapeutic potential. We discuss how molecular profiling of tumors and liquid biopsies can generate extensive multi-omics datasets, which can be leveraged through machine learning-based analytical approaches for patient stratification. Addressing these challenges is essential for advancing the clinical integration of ferroptosis-driven treatments in cancer care.https://doi.org/10.1186/s12915-025-02154-6FerroptosisCancerMachine learningLiquid biopsyCell-free DNADNA methylation |
| spellingShingle | Roberto Fernández-Acosta Iuliana Vintea Ine Koeken Behrouz Hassannia Tom Vanden Berghe Harnessing ferroptosis for precision oncology: challenges and prospects BMC Biology Ferroptosis Cancer Machine learning Liquid biopsy Cell-free DNA DNA methylation |
| title | Harnessing ferroptosis for precision oncology: challenges and prospects |
| title_full | Harnessing ferroptosis for precision oncology: challenges and prospects |
| title_fullStr | Harnessing ferroptosis for precision oncology: challenges and prospects |
| title_full_unstemmed | Harnessing ferroptosis for precision oncology: challenges and prospects |
| title_short | Harnessing ferroptosis for precision oncology: challenges and prospects |
| title_sort | harnessing ferroptosis for precision oncology challenges and prospects |
| topic | Ferroptosis Cancer Machine learning Liquid biopsy Cell-free DNA DNA methylation |
| url | https://doi.org/10.1186/s12915-025-02154-6 |
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