Mitochondrial pyruvate carrier inhibits tumor growth by Bmi1 ubiquitination in renal cell carcinoma progression

Mitochondrial pyruvate carrier inhibits tumor growth by Bmi1 ubiquitination in renal cell carcinoma progression

Abstract Mitochondrial pyruvate carrier (MPC), composed of MPC1 and MPC2, plays a pivotal role in regulating cancer metabolism. While previous studies have implicated MPC1 in tumor progression, the specific function of MPC2 in renal cell carcinoma (RCC) remains largely unclear. In this study, we fou...

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Bibliographic Details
Main Authors: Dan Jian, Nana Hu, Rong He, Le He, He Xiao, Xingqiao Peng, Yang Peng, Yuxin Yang, Xiaoyan Dai, Dong Wang, Yan Feng, Nan Dai, Qian Chen
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
MPC2
MPC1
RCC
Bmi1
Ubiquitination
Online Access:https://doi.org/10.1007/s12672-025-03053-6
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https://doi.org/10.1007/s12672-025-03053-6

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