Neurotoxic and neuroprotective effects of homocysteine and hydrogen sulfide
Homocysteine is a sulfhydryl-containing amino acid derived from methionine. The cellular concentration of homocysteine is regulated by two key pathways: remethylation back to methionine or transsulfuration to cysteine with simultaneous production of hydrogen sulfide (H2S). Homocysteine levels increa...
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| Format: | Article |
| Language: | English |
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Kazan Federal University
2018-12-01
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| Series: | Учёные записки Казанского университета: Серия Естественные науки |
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| Online Access: | https://kpfu.ru/neurotoxic-and-neuroprotective-effects-of_382307.html |
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| author | G.F. Sitdikova A. Hermann A.V. Yakovlev |
| author_facet | G.F. Sitdikova A. Hermann A.V. Yakovlev |
| author_sort | G.F. Sitdikova |
| collection | DOAJ |
| description | Homocysteine is a sulfhydryl-containing amino acid derived from methionine. The cellular concentration of homocysteine is regulated by two key pathways: remethylation back to methionine or transsulfuration to cysteine with simultaneous production of hydrogen sulfide (H2S). Homocysteine levels increase in different conditions, including genetic factors, diet, life style or miscellaneous medication. Elevated levels of the homocysteine, called hyperhomocysteinemia (hHcy), are associated with a higher risk of neurovascular diseases, dementia, developmental impairments or epilepsy. Oxidative stress is one of the common mechanisms of homocysteine-induced disorders. H2S as an established gasotransmitter implicated in the regulation of numerous physiological functions is also well-known for its neuroprotective potential. The recent data indicate that the level of H2S decreases in hHcy conditions, which may mediate homocysteine-induced neurotoxicity. This review summarizes the available data on homocysteine and H2S metabolism and mechanisms of H2S mediating neuroprotection and can be helpful in searching for ways to prevent homocysteine-induced neurotoxicity. |
| format | Article |
| id | doaj-art-81b3eae8aeb14f39b18fb3f615870197 |
| institution | DOAJ |
| issn | 2542-064X 2500-218X |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Kazan Federal University |
| record_format | Article |
| series | Учёные записки Казанского университета: Серия Естественные науки |
| spelling | doaj-art-81b3eae8aeb14f39b18fb3f6158701972025-08-20T02:56:11ZengKazan Federal UniversityУчёные записки Казанского университета: Серия Естественные науки2542-064X2500-218X2018-12-011604686704Neurotoxic and neuroprotective effects of homocysteine and hydrogen sulfideG.F. Sitdikova0A. Hermann1A.V. Yakovlev2Kazan Federal University, Kazan, 420008 RussiaUniversity of Salzburg, Salzburg, A-5020 AustriaKazan Federal University, Kazan, 420008 RussiaHomocysteine is a sulfhydryl-containing amino acid derived from methionine. The cellular concentration of homocysteine is regulated by two key pathways: remethylation back to methionine or transsulfuration to cysteine with simultaneous production of hydrogen sulfide (H2S). Homocysteine levels increase in different conditions, including genetic factors, diet, life style or miscellaneous medication. Elevated levels of the homocysteine, called hyperhomocysteinemia (hHcy), are associated with a higher risk of neurovascular diseases, dementia, developmental impairments or epilepsy. Oxidative stress is one of the common mechanisms of homocysteine-induced disorders. H2S as an established gasotransmitter implicated in the regulation of numerous physiological functions is also well-known for its neuroprotective potential. The recent data indicate that the level of H2S decreases in hHcy conditions, which may mediate homocysteine-induced neurotoxicity. This review summarizes the available data on homocysteine and H2S metabolism and mechanisms of H2S mediating neuroprotection and can be helpful in searching for ways to prevent homocysteine-induced neurotoxicity.https://kpfu.ru/neurotoxic-and-neuroprotective-effects-of_382307.htmlhomocysteinehyperhomocysteinemiacystathionine beta synthasehydrogen sulfideoxidative stressglutamate receptorsca2+-activated k+-channelsneurodegenerationcognitive dysfunctions |
| spellingShingle | G.F. Sitdikova A. Hermann A.V. Yakovlev Neurotoxic and neuroprotective effects of homocysteine and hydrogen sulfide Учёные записки Казанского университета: Серия Естественные науки homocysteine hyperhomocysteinemia cystathionine beta synthase hydrogen sulfide oxidative stress glutamate receptors ca2+-activated k+-channels neurodegeneration cognitive dysfunctions |
| title | Neurotoxic and neuroprotective effects of homocysteine and hydrogen sulfide |
| title_full | Neurotoxic and neuroprotective effects of homocysteine and hydrogen sulfide |
| title_fullStr | Neurotoxic and neuroprotective effects of homocysteine and hydrogen sulfide |
| title_full_unstemmed | Neurotoxic and neuroprotective effects of homocysteine and hydrogen sulfide |
| title_short | Neurotoxic and neuroprotective effects of homocysteine and hydrogen sulfide |
| title_sort | neurotoxic and neuroprotective effects of homocysteine and hydrogen sulfide |
| topic | homocysteine hyperhomocysteinemia cystathionine beta synthase hydrogen sulfide oxidative stress glutamate receptors ca2+-activated k+-channels neurodegeneration cognitive dysfunctions |
| url | https://kpfu.ru/neurotoxic-and-neuroprotective-effects-of_382307.html |
| work_keys_str_mv | AT gfsitdikova neurotoxicandneuroprotectiveeffectsofhomocysteineandhydrogensulfide AT ahermann neurotoxicandneuroprotectiveeffectsofhomocysteineandhydrogensulfide AT avyakovlev neurotoxicandneuroprotectiveeffectsofhomocysteineandhydrogensulfide |