Effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarction
Aim. This study aims to investigate the effect of senile asthenia syndrome (SAS) on the cardiovascular mortality risk within 12 months in patients over 70 years of age with myocardial infarction.Material and methods. We performed a retrospective study of 92 patients over 70 years of age with myocard...
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«FIRMA «SILICEA» LLC
2023-07-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5391 |
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| author | O. Yu. Aydumova Yu. V. Shchukin M. V. Piskunov |
| author_facet | O. Yu. Aydumova Yu. V. Shchukin M. V. Piskunov |
| author_sort | O. Yu. Aydumova |
| collection | DOAJ |
| description | Aim. This study aims to investigate the effect of senile asthenia syndrome (SAS) on the cardiovascular mortality risk within 12 months in patients over 70 years of age with myocardial infarction.Material and methods. We performed a retrospective study of 92 patients over 70 years of age with myocardial infarction, who agreed to participate. To detect senile asthenia syndrome, we used the questionnaire "Age is not a hindrance". We estimated the anamnestic data, and also laboratory and instrumental parameters. The follow-up period was 12 months. As an end-point, the onset of an adverse event — cardiovascular death was chosen. Statistical nonparametric methods, ROC analysis, Kaplan-Meier survival analysis (p<0,05) were used.Results. In 12 months, 19 patients (20,65%) met the end-point. The median (25%; 75%-quartile) of the numbers of points according to the questionnaire "Age is not a hindrance" was significantly higher in the group of dead patients than in the group without adverse outcomes — 4 (3; 5) and 2 (1; 4) points (p<0,001). When gaining 3 or more points according to the questionnaire "Age is not a hindrance", risk ratio of cardiovascular death within 12 months was 1,72; 95% confidence interval: 1,28-2,30 (p=0,001). In conduction of ROC analysis to predict adverse outcome when gaining 3 or more points according to the questionnaire "Age is not a hindrance", the area under the curve (AUC) was 0,78 (p<0,001), sensitivity — 89%, specificity — 60%.Conclusion. The risk of cardiovascular death within 12 months after myocardial infarction in patients over 70 years of age with SAS increases by 72%. The inclusion of the results from the questionnaire "Age is not a hindrance" into prognostic models, and the SAS estimation in this cohort of patients will improve the risk stratification. |
| format | Article |
| id | doaj-art-81b3b7cf2fa34587803ad1f22011664d |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2023-07-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-81b3b7cf2fa34587803ad1f22011664d2025-08-20T03:43:40Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-07-01282S10.15829/1560-4071-2023-53913840Effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarctionO. Yu. Aydumova0Yu. V. Shchukin1M. V. Piskunov2Samara State Medical UniversitySamara State Medical UniversityFederal State Budgetary Educational Institution of Higher Education «Samara State Medical University» of the Ministry of Health of the Russian FederationAim. This study aims to investigate the effect of senile asthenia syndrome (SAS) on the cardiovascular mortality risk within 12 months in patients over 70 years of age with myocardial infarction.Material and methods. We performed a retrospective study of 92 patients over 70 years of age with myocardial infarction, who agreed to participate. To detect senile asthenia syndrome, we used the questionnaire "Age is not a hindrance". We estimated the anamnestic data, and also laboratory and instrumental parameters. The follow-up period was 12 months. As an end-point, the onset of an adverse event — cardiovascular death was chosen. Statistical nonparametric methods, ROC analysis, Kaplan-Meier survival analysis (p<0,05) were used.Results. In 12 months, 19 patients (20,65%) met the end-point. The median (25%; 75%-quartile) of the numbers of points according to the questionnaire "Age is not a hindrance" was significantly higher in the group of dead patients than in the group without adverse outcomes — 4 (3; 5) and 2 (1; 4) points (p<0,001). When gaining 3 or more points according to the questionnaire "Age is not a hindrance", risk ratio of cardiovascular death within 12 months was 1,72; 95% confidence interval: 1,28-2,30 (p=0,001). In conduction of ROC analysis to predict adverse outcome when gaining 3 or more points according to the questionnaire "Age is not a hindrance", the area under the curve (AUC) was 0,78 (p<0,001), sensitivity — 89%, specificity — 60%.Conclusion. The risk of cardiovascular death within 12 months after myocardial infarction in patients over 70 years of age with SAS increases by 72%. The inclusion of the results from the questionnaire "Age is not a hindrance" into prognostic models, and the SAS estimation in this cohort of patients will improve the risk stratification.https://russjcardiol.elpub.ru/jour/article/view/5391myocardial infarctionsenile asthenia syndromefrailty syndromemedium-term forecastcardiovascular death |
| spellingShingle | O. Yu. Aydumova Yu. V. Shchukin M. V. Piskunov Effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarction Российский кардиологический журнал myocardial infarction senile asthenia syndrome frailty syndrome medium-term forecast cardiovascular death |
| title | Effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarction |
| title_full | Effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarction |
| title_fullStr | Effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarction |
| title_full_unstemmed | Effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarction |
| title_short | Effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarction |
| title_sort | effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarction |
| topic | myocardial infarction senile asthenia syndrome frailty syndrome medium-term forecast cardiovascular death |
| url | https://russjcardiol.elpub.ru/jour/article/view/5391 |
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