Assessment of Salivary Neutrophil Gelatinase-Associated Lipocalin Levels in Diseased and Healthy Periodontium
Background: periodontal disease is one of the most frequent human diseases. Depending on the severity of the inflammation, the destructive process may affect both the gingiva (gingivitis) and/or the periodontal ligament and alveolar bone that surround and support the teeth (periodontitis). Ob...
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University of Baghdad/ Al-Kindy College of Medicine
2024-12-01
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| Series: | مجله كليه طب الكندي |
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| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/956 |
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| _version_ | 1850117772390957056 |
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| author | Muntadhr Al-Musawi Omar Ali |
| author_facet | Muntadhr Al-Musawi Omar Ali |
| author_sort | Muntadhr Al-Musawi |
| collection | DOAJ |
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Background: periodontal disease is one of the most frequent human diseases. Depending on the severity of the inflammation, the destructive process may affect both the gingiva (gingivitis) and/or the periodontal ligament and alveolar bone that surround and support the teeth (periodontitis).
Objective: The study aimed to determine and compare the level of salivary Neutrophil gelatinase-associated lipocalin in periodontal health and disease (gingivitis and periodontitis stage I-III).
Subjects and Methods: A total of 90 individuals participated in the research separated into five groups, clinically healthy (n=10), gingivitis (n=20), stage I periodontitis (n=20), stage II periodontitis (n=20) and stage III periodontitis (n=20), periodontal parameters were recorded, and the level of salivary Neutrophil gelatinase-associated lipocalin was assessed by using the enzyme-linked immunosorbent assay.
Results: Neutrophil gelatinase-associated lipocalin salivary level was significantly higher (p<0.05) in periodontal disease groups compared to healthy controls. A statistically significant difference was also found between gingivitis and advanced periodontitis (stageII-III) (p<0.05). No significant difference (p>0.05) was found between different stages of periodontitis.
Conclusions: Neutrophil gelatinase-associated lipocalin is associated with periodontal diseases and my play a role in its pathogenesis
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| format | Article |
| id | doaj-art-81b2b02ae4e24d9986bb7f0f304a4c52 |
| institution | OA Journals |
| issn | 1810-9543 2521-4365 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj-art-81b2b02ae4e24d9986bb7f0f304a4c522025-08-20T02:36:02ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652024-12-0120310.47723/mh7wp335882Assessment of Salivary Neutrophil Gelatinase-Associated Lipocalin Levels in Diseased and Healthy PeriodontiumMuntadhr Al-Musawi0https://orcid.org/0000-0002-3842-412XOmar Ali1College of Dentistry, The Islamic University, Najaf, IraqDepartment of Periodontology, College of Dentistry, University of Baghdad, Baghdad, Iraq Background: periodontal disease is one of the most frequent human diseases. Depending on the severity of the inflammation, the destructive process may affect both the gingiva (gingivitis) and/or the periodontal ligament and alveolar bone that surround and support the teeth (periodontitis). Objective: The study aimed to determine and compare the level of salivary Neutrophil gelatinase-associated lipocalin in periodontal health and disease (gingivitis and periodontitis stage I-III). Subjects and Methods: A total of 90 individuals participated in the research separated into five groups, clinically healthy (n=10), gingivitis (n=20), stage I periodontitis (n=20), stage II periodontitis (n=20) and stage III periodontitis (n=20), periodontal parameters were recorded, and the level of salivary Neutrophil gelatinase-associated lipocalin was assessed by using the enzyme-linked immunosorbent assay. Results: Neutrophil gelatinase-associated lipocalin salivary level was significantly higher (p<0.05) in periodontal disease groups compared to healthy controls. A statistically significant difference was also found between gingivitis and advanced periodontitis (stageII-III) (p<0.05). No significant difference (p>0.05) was found between different stages of periodontitis. Conclusions: Neutrophil gelatinase-associated lipocalin is associated with periodontal diseases and my play a role in its pathogenesis https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/956ELISAGingivitisNeutrophil gelatinase-associated lipocalinPeriodontitisSalivary biomarker |
| spellingShingle | Muntadhr Al-Musawi Omar Ali Assessment of Salivary Neutrophil Gelatinase-Associated Lipocalin Levels in Diseased and Healthy Periodontium مجله كليه طب الكندي ELISA Gingivitis Neutrophil gelatinase-associated lipocalin Periodontitis Salivary biomarker |
| title | Assessment of Salivary Neutrophil Gelatinase-Associated Lipocalin Levels in Diseased and Healthy Periodontium |
| title_full | Assessment of Salivary Neutrophil Gelatinase-Associated Lipocalin Levels in Diseased and Healthy Periodontium |
| title_fullStr | Assessment of Salivary Neutrophil Gelatinase-Associated Lipocalin Levels in Diseased and Healthy Periodontium |
| title_full_unstemmed | Assessment of Salivary Neutrophil Gelatinase-Associated Lipocalin Levels in Diseased and Healthy Periodontium |
| title_short | Assessment of Salivary Neutrophil Gelatinase-Associated Lipocalin Levels in Diseased and Healthy Periodontium |
| title_sort | assessment of salivary neutrophil gelatinase associated lipocalin levels in diseased and healthy periodontium |
| topic | ELISA Gingivitis Neutrophil gelatinase-associated lipocalin Periodontitis Salivary biomarker |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/956 |
| work_keys_str_mv | AT muntadhralmusawi assessmentofsalivaryneutrophilgelatinaseassociatedlipocalinlevelsindiseasedandhealthyperiodontium AT omarali assessmentofsalivaryneutrophilgelatinaseassociatedlipocalinlevelsindiseasedandhealthyperiodontium |