Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review
ABSTRACT Carbimazole, a thionamide derivative, is widely used for hyperthyroidism but carries a rare risk of hepatotoxicity, including cholestatic injury. A 42‐year‐old man developed severe cholestatic jaundice 4 weeks after carbimazole initiation. Laboratory findings showed marked hyperbilirubinemi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70498 |
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| author | Bassem Al Hariri Mohammed Omer Elbadawi Elhassan Hadil Altaj Altrify Alsidig Muad Abdi Hassan Abdalrahman Mohammed Mostafa Memon Noor Illahi |
| author_facet | Bassem Al Hariri Mohammed Omer Elbadawi Elhassan Hadil Altaj Altrify Alsidig Muad Abdi Hassan Abdalrahman Mohammed Mostafa Memon Noor Illahi |
| author_sort | Bassem Al Hariri |
| collection | DOAJ |
| description | ABSTRACT Carbimazole, a thionamide derivative, is widely used for hyperthyroidism but carries a rare risk of hepatotoxicity, including cholestatic injury. A 42‐year‐old man developed severe cholestatic jaundice 4 weeks after carbimazole initiation. Laboratory findings showed marked hyperbilirubinemia (peak: 650 μmol/L) with elevated ALP (366 U/L). Viral, autoimmune, and biliary causes were excluded. Liver biopsy confirmed cholestasis. Carbimazole was discontinued, corticosteroids initiated, and radioiodine therapy planned. Bilirubin levels gradually improved over 8 weeks. Carbimazole‐induced cholestasis, though rare, necessitates prompt recognition and alternative hyperthyroidism management. Routine liver monitoring is crucial. |
| format | Article |
| id | doaj-art-81ab3ddbf2c34663bff4b4d59f4e8e39 |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-81ab3ddbf2c34663bff4b4d59f4e8e392025-08-20T03:47:21ZengWileyClinical Case Reports2050-09042025-06-01136n/an/a10.1002/ccr3.70498Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature ReviewBassem Al Hariri0Mohammed Omer Elbadawi Elhassan1Hadil Altaj Altrify Alsidig2Muad Abdi Hassan3Abdalrahman Mohammed Mostafa4Memon Noor Illahi5Department of Medicine Hamad Medical Corporation Doha QatarMedical Education Department Hamad Medical Corporation Doha QatarMedical Education Department Hamad Medical Corporation Doha QatarMedical Education Department Hamad Medical Corporation Doha QatarDepartment of Medicine Hamad Medical Corporation Doha QatarDepartment of Medicine Hamad Medical Corporation Doha QatarABSTRACT Carbimazole, a thionamide derivative, is widely used for hyperthyroidism but carries a rare risk of hepatotoxicity, including cholestatic injury. A 42‐year‐old man developed severe cholestatic jaundice 4 weeks after carbimazole initiation. Laboratory findings showed marked hyperbilirubinemia (peak: 650 μmol/L) with elevated ALP (366 U/L). Viral, autoimmune, and biliary causes were excluded. Liver biopsy confirmed cholestasis. Carbimazole was discontinued, corticosteroids initiated, and radioiodine therapy planned. Bilirubin levels gradually improved over 8 weeks. Carbimazole‐induced cholestasis, though rare, necessitates prompt recognition and alternative hyperthyroidism management. Routine liver monitoring is crucial.https://doi.org/10.1002/ccr3.70498carbimazolecholestatic liver injurydrug‐induced liver injury (DILI)hepatotoxicityhyperthyroidismthionamide therapy |
| spellingShingle | Bassem Al Hariri Mohammed Omer Elbadawi Elhassan Hadil Altaj Altrify Alsidig Muad Abdi Hassan Abdalrahman Mohammed Mostafa Memon Noor Illahi Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review Clinical Case Reports carbimazole cholestatic liver injury drug‐induced liver injury (DILI) hepatotoxicity hyperthyroidism thionamide therapy |
| title | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| title_full | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| title_fullStr | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| title_full_unstemmed | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| title_short | Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review |
| title_sort | cholestatic hepatic injury induced by carbimazole a case report and a thorough literature review |
| topic | carbimazole cholestatic liver injury drug‐induced liver injury (DILI) hepatotoxicity hyperthyroidism thionamide therapy |
| url | https://doi.org/10.1002/ccr3.70498 |
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