Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancers
Conclusion: In this study, we established the role of negative ERCC1 expression in predicting the response to chemotherapy in neoadjuvant TNBC. Therefore, ERCC1 can be used as a predictive marker to stratify patients who will benefit from neoadjuvant therapy. Moreover, we also noted an association b...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | The Breast Journal |
| Online Access: | http://dx.doi.org/10.1155/tbj/8410670 |
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| _version_ | 1850231664362389504 |
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| author | Atif Ali Hashmi Yumna Ajaz Muhsana Sajjad Fazail Zia Muhammad Irfan Syed Muhammad Abu Bakar Erum Yousuf Khan Naveen Faridi |
| author_facet | Atif Ali Hashmi Yumna Ajaz Muhsana Sajjad Fazail Zia Muhammad Irfan Syed Muhammad Abu Bakar Erum Yousuf Khan Naveen Faridi |
| author_sort | Atif Ali Hashmi |
| collection | DOAJ |
| description | Conclusion: In this study, we established the role of negative ERCC1 expression in predicting the response to chemotherapy in neoadjuvant TNBC. Therefore, ERCC1 can be used as a predictive marker to stratify patients who will benefit from neoadjuvant therapy. Moreover, we also noted an association between ERCC1 expression and nodal metastasis; however, more large-scale studies are needed to establish its role as a prognostic biomarker in TNBC. |
| format | Article |
| id | doaj-art-81aa624dd8ff413f8f3f86221cea9b68 |
| institution | OA Journals |
| issn | 1524-4741 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Breast Journal |
| spelling | doaj-art-81aa624dd8ff413f8f3f86221cea9b682025-08-20T02:03:27ZengWileyThe Breast Journal1524-47412025-01-01202510.1155/tbj/8410670Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast CancersAtif Ali Hashmi0Yumna Ajaz1Muhsana Sajjad2Fazail Zia3Muhammad Irfan4Syed Muhammad Abu Bakar5Erum Yousuf Khan6Naveen Faridi7Department of HistopathologyDepartment of HistopathologyDepartment of PathologyDepartment of PathologyDepartment of StatisticsDepartment of HistopathologyDepartment of HistopathologyDepartment of HistopathologyConclusion: In this study, we established the role of negative ERCC1 expression in predicting the response to chemotherapy in neoadjuvant TNBC. Therefore, ERCC1 can be used as a predictive marker to stratify patients who will benefit from neoadjuvant therapy. Moreover, we also noted an association between ERCC1 expression and nodal metastasis; however, more large-scale studies are needed to establish its role as a prognostic biomarker in TNBC.http://dx.doi.org/10.1155/tbj/8410670 |
| spellingShingle | Atif Ali Hashmi Yumna Ajaz Muhsana Sajjad Fazail Zia Muhammad Irfan Syed Muhammad Abu Bakar Erum Yousuf Khan Naveen Faridi Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancers The Breast Journal |
| title | Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancers |
| title_full | Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancers |
| title_fullStr | Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancers |
| title_full_unstemmed | Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancers |
| title_short | Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancers |
| title_sort | predictive value of excision repair cross complementation group 1 ercc1 by immunohistochemistry for determining neoadjuvant chemotherapy response in triple negative breast cancers |
| url | http://dx.doi.org/10.1155/tbj/8410670 |
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