Tetramethylpyrazine enhances neuroprotection and plasticity in cerebral ischemia-reperfusion injury via RhoA/ROCK2 pathway inhibition

Tetramethylpyrazine enhances neuroprotection and plasticity in cerebral ischemia-reperfusion injury via RhoA/ROCK2 pathway inhibition

Tetramethylpyrazine (TMP) is an active component of the Chuanxiong, effectively crosses blood-brain barrier (BBB). It exhibits neuroprotective potential in cerebral ischemia-reperfusion injury (CIRI). This study performed middle cerebral artery occlusion/reperfusion (MCAO/R) surgery in rats to evalu...

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Bibliographic Details
Main Authors: Yixin Zhang, Xin Zhang, Xiaocheng Shi, Weijing Liao, Junbin Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
tetramethylpyrazine
cerebral ischemia-reperfusion injury
neuroplasticity
neuroprotection
nature products
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1594283/full
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