Synthesis, Characterization, and Biological Activity Study of New Heterocyclic Compounds
The synthesis of novel heterocyclic compounds is achieved through a multi-step process involving azo dye (<b>S1</b>), ester (<b>S2</b>), and hydrazide (<b>S3</b>). Initially, azo dye (<b>S1</b>) is synthesized through the reaction between resorcinol an...
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2024-01-01
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| author | Shahad M. Alsafy Nour Abd Alrazzak |
| author_facet | Shahad M. Alsafy Nour Abd Alrazzak |
| author_sort | Shahad M. Alsafy |
| collection | DOAJ |
| description | The synthesis of novel heterocyclic compounds is achieved through a multi-step process involving azo dye (<b>S1</b>), ester (<b>S2</b>), and hydrazide (<b>S3</b>). Initially, azo dye (<b>S1</b>) is synthesized through the reaction between resorcinol and p-aminobenzoic acid. Subsequently, ester (<b>S2</b>) is formed by reacting azo dye (<b>S1</b>) with concentrated sulfuric acid. Hydrazide (<b>S3</b>) is then synthesized by reacting ester (<b>S2</b>) with 80% hydrazine hydrate. Further reactions of hydrazide (<b>S3</b>) with various anhydrides (maleic anhydride, phthalic anhydride, 3-nitrophthalic anhydride, and succinic anhydride) result in cyclization facilitated by acetic acid, yielding six-membered heterocyclic compounds. Additionally, compound <b>S3</b> undergoes cyclization with acetyl acetone, ethyl acetoacetate, methyl acetoacetate, and diethyl malonate to produce five-membered heterocyclic compounds. The biological activity of these synthesized compounds is also investigated. Characterization of the prepared compounds is performed using techniques such as Fourier-Transform Infrared Spectroscopy (FT-IR), Proton Nuclear Magnetic Resonance (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mrow></mrow><mn>1</mn></msup></semantics></math></inline-formula>HNMR), Carbon-13 Nuclear Magnetic Resonance (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mrow></mrow><mn>13</mn></msup></semantics></math></inline-formula>C-NMR), and Elemental Analysis (CHNS). |
| format | Article |
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| institution | Kabale University |
| issn | 2673-4591 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Engineering Proceedings |
| spelling | doaj-art-81a334b2f67a4e7b90500607f0a804af2025-08-20T03:43:33ZengMDPI AGEngineering Proceedings2673-45912024-01-0159117810.3390/engproc2023059178Synthesis, Characterization, and Biological Activity Study of New Heterocyclic CompoundsShahad M. Alsafy0Nour Abd Alrazzak1Department of Chemistry, College of Science for Women, University of Babylon, Hilla 5001, IraqDepartment of Chemistry, College of Science for Women, University of Babylon, Hilla 5001, IraqThe synthesis of novel heterocyclic compounds is achieved through a multi-step process involving azo dye (<b>S1</b>), ester (<b>S2</b>), and hydrazide (<b>S3</b>). Initially, azo dye (<b>S1</b>) is synthesized through the reaction between resorcinol and p-aminobenzoic acid. Subsequently, ester (<b>S2</b>) is formed by reacting azo dye (<b>S1</b>) with concentrated sulfuric acid. Hydrazide (<b>S3</b>) is then synthesized by reacting ester (<b>S2</b>) with 80% hydrazine hydrate. Further reactions of hydrazide (<b>S3</b>) with various anhydrides (maleic anhydride, phthalic anhydride, 3-nitrophthalic anhydride, and succinic anhydride) result in cyclization facilitated by acetic acid, yielding six-membered heterocyclic compounds. Additionally, compound <b>S3</b> undergoes cyclization with acetyl acetone, ethyl acetoacetate, methyl acetoacetate, and diethyl malonate to produce five-membered heterocyclic compounds. The biological activity of these synthesized compounds is also investigated. Characterization of the prepared compounds is performed using techniques such as Fourier-Transform Infrared Spectroscopy (FT-IR), Proton Nuclear Magnetic Resonance (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mrow></mrow><mn>1</mn></msup></semantics></math></inline-formula>HNMR), Carbon-13 Nuclear Magnetic Resonance (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mrow></mrow><mn>13</mn></msup></semantics></math></inline-formula>C-NMR), and Elemental Analysis (CHNS).https://www.mdpi.com/2673-4591/59/1/178resorcinolazo dyespyridazinephthalazinepyrazolebiological activity |
| spellingShingle | Shahad M. Alsafy Nour Abd Alrazzak Synthesis, Characterization, and Biological Activity Study of New Heterocyclic Compounds Engineering Proceedings resorcinol azo dyes pyridazine phthalazine pyrazole biological activity |
| title | Synthesis, Characterization, and Biological Activity Study of New Heterocyclic Compounds |
| title_full | Synthesis, Characterization, and Biological Activity Study of New Heterocyclic Compounds |
| title_fullStr | Synthesis, Characterization, and Biological Activity Study of New Heterocyclic Compounds |
| title_full_unstemmed | Synthesis, Characterization, and Biological Activity Study of New Heterocyclic Compounds |
| title_short | Synthesis, Characterization, and Biological Activity Study of New Heterocyclic Compounds |
| title_sort | synthesis characterization and biological activity study of new heterocyclic compounds |
| topic | resorcinol azo dyes pyridazine phthalazine pyrazole biological activity |
| url | https://www.mdpi.com/2673-4591/59/1/178 |
| work_keys_str_mv | AT shahadmalsafy synthesischaracterizationandbiologicalactivitystudyofnewheterocycliccompounds AT nourabdalrazzak synthesischaracterizationandbiologicalactivitystudyofnewheterocycliccompounds |