REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling

REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling

Abstract Background Regenerating family member 3A (REG3A) is involved in the development of multiple malignant tumors, including pancreatic ductal adenocarcinoma (PDAC). However, any role of REG3A in PDAC remains controversial due to its unclear tissue localization or direct receptors, and complex d...

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Main Authors: Xiaojing Ren, Yunfei Teng, Kunxin Xie, Xiao He, Gang Chen, Kaini Zhang, Qingyi Liao, Jia Zhang, Xiaohang Zhou, Yating Zhu, Wenyu Song, Yuege Lin, Yi Zhang, Zhijian Xu, Noriaki Maeshige, Xiubin Liang, Dongming Su, Peng Sun, Ying Ding
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
REG3A
Pancreatic ductal adenocarcinoma
Peritumoral acinar cell
Epidermal growth factor receptor (EGFR)
Paracrine
Online Access:https://doi.org/10.1186/s12964-025-02103-4
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