Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia
Introduction: Lyme disease has been well-described in the North America and European countries. However, information is still very limited in the developing countries including Malaysia. The Orang Asli (OA), the indigenous people of Peninsular Malaysia reside mostly in the forest and forest fringe...
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The Journal of Infection in Developing Countries
2019-05-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/11001 |
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| author | Chee-Sieng Khor Habibi Hassan Nurul-Farhana Mohd-Rahim Josephine Rebecca Chandren Siti-Sarah Nore Jefree Johari Shih-Keng Loong Juraina Abd-Jamil Jing-Jing Khoo Hai-Yen Lee Brian L Pike Wong Li-Ping Yvonne Ai-Lian Lim Sazaly AbuBakar |
| author_facet | Chee-Sieng Khor Habibi Hassan Nurul-Farhana Mohd-Rahim Josephine Rebecca Chandren Siti-Sarah Nore Jefree Johari Shih-Keng Loong Juraina Abd-Jamil Jing-Jing Khoo Hai-Yen Lee Brian L Pike Wong Li-Ping Yvonne Ai-Lian Lim Sazaly AbuBakar |
| author_sort | Chee-Sieng Khor |
| collection | DOAJ |
| description |
Introduction: Lyme disease has been well-described in the North America and European countries. However, information is still very limited in the developing countries including Malaysia. The Orang Asli (OA), the indigenous people of Peninsular Malaysia reside mostly in the forest and forest fringe areas abundant with the vector for Lyme disease. Here, we described the seroprevalence of Borellia burgdorferi (B. burgdorferi) among the OA and demographic variables that could be associated with seroprevalence.
Methodology: A total of 16 OA villages distributed across 8 states in Peninsular Malaysia participated in this study. Sera obtained from 904 OA volunteers were screened for anti-B. burgdorferi IgG antibodies. ELISA results obtained and demographic information collected were analysed to identify possible variables associated with seroprevalence.
Results: A total of 73 (8.1%) OA tested positive for anti-B. burgdorferi IgG antibodies. Among all the variables examined, village of residence (p = 0.045) was the only significant predictor for seropositivity. High (> 10.0%) prevalence was associated with three OA villages. Those living in one particular village were 1.65 times more likely to be seropositive as compared to other OA villages. Age, gender, marital status, household size, level of education, monthly household income and occupation were not significant predictors for seropositivity.
Conclusion: Results of the present study support earlier findings that B. burgdorferi infection among Malaysians is currently under-recognized. Further studies will be needed at these locations to confirm the presence of Lyme disease among these populations.
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| format | Article |
| id | doaj-art-819f84a966e6441dbd44a0d85fb4d266 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2019-05-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-819f84a966e6441dbd44a0d85fb4d2662025-08-20T02:57:52ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802019-05-01130510.3855/jidc.11001Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular MalaysiaChee-Sieng Khor0Habibi Hassan1Nurul-Farhana Mohd-Rahim2Josephine Rebecca Chandren3Siti-Sarah Nore4Jefree Johari5Shih-Keng Loong6Juraina Abd-Jamil7Jing-Jing Khoo8Hai-Yen Lee9Brian L Pike10Wong Li-Ping11Yvonne Ai-Lian Lim12Sazaly AbuBakar13Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, MalaysiaDepartment of Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, MalaysiaU.S. Naval Medical Research Center - Asia, SingaporeDepartment of Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaDepartment of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, Malaysia Introduction: Lyme disease has been well-described in the North America and European countries. However, information is still very limited in the developing countries including Malaysia. The Orang Asli (OA), the indigenous people of Peninsular Malaysia reside mostly in the forest and forest fringe areas abundant with the vector for Lyme disease. Here, we described the seroprevalence of Borellia burgdorferi (B. burgdorferi) among the OA and demographic variables that could be associated with seroprevalence. Methodology: A total of 16 OA villages distributed across 8 states in Peninsular Malaysia participated in this study. Sera obtained from 904 OA volunteers were screened for anti-B. burgdorferi IgG antibodies. ELISA results obtained and demographic information collected were analysed to identify possible variables associated with seroprevalence. Results: A total of 73 (8.1%) OA tested positive for anti-B. burgdorferi IgG antibodies. Among all the variables examined, village of residence (p = 0.045) was the only significant predictor for seropositivity. High (> 10.0%) prevalence was associated with three OA villages. Those living in one particular village were 1.65 times more likely to be seropositive as compared to other OA villages. Age, gender, marital status, household size, level of education, monthly household income and occupation were not significant predictors for seropositivity. Conclusion: Results of the present study support earlier findings that B. burgdorferi infection among Malaysians is currently under-recognized. Further studies will be needed at these locations to confirm the presence of Lyme disease among these populations. https://jidc.org/index.php/journal/article/view/11001Lyme diseaseBorrelia burgdorferiMalaysiaOrang Asliticksinfectious diseases |
| spellingShingle | Chee-Sieng Khor Habibi Hassan Nurul-Farhana Mohd-Rahim Josephine Rebecca Chandren Siti-Sarah Nore Jefree Johari Shih-Keng Loong Juraina Abd-Jamil Jing-Jing Khoo Hai-Yen Lee Brian L Pike Wong Li-Ping Yvonne Ai-Lian Lim Sazaly AbuBakar Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia Journal of Infection in Developing Countries Lyme disease Borrelia burgdorferi Malaysia Orang Asli ticks infectious diseases |
| title | Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia |
| title_full | Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia |
| title_fullStr | Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia |
| title_full_unstemmed | Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia |
| title_short | Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia |
| title_sort | seroprevalence of borrelia burgdorferi among the indigenous people orang asli of peninsular malaysia |
| topic | Lyme disease Borrelia burgdorferi Malaysia Orang Asli ticks infectious diseases |
| url | https://jidc.org/index.php/journal/article/view/11001 |
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