Application of Statistical Experimental Design and Surface Plot Technique to Optimize Oxygenated Apatite Synthesis
This work deals with oxygenated apatite synthesis from calcium chloride and phosphoric acid using a wet precipitation method. An experimental design is applied to precise the influence of the synthesis parameters (pH of the reaction medium, atomic ratio Ca/P of the reagents, concentration of the cal...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2020/1034959 |
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| _version_ | 1832547788384108544 |
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| author | Soumia Belouafa Hassan Chaair Khalid Digua |
| author_facet | Soumia Belouafa Hassan Chaair Khalid Digua |
| author_sort | Soumia Belouafa |
| collection | DOAJ |
| description | This work deals with oxygenated apatite synthesis from calcium chloride and phosphoric acid using a wet precipitation method. An experimental design is applied to precise the influence of the synthesis parameters (pH of the reaction medium, atomic ratio Ca/P of the reagents, concentration of the calcium solution (Ca2+), temperature of the reaction medium (T), and duration of the reaction (D)) on the chemical composition (Ca/P molar ratio, % O2, and % O22−). An empirical model was developed and validated by applying the ANOVA analysis incorporating the interaction effects of all parameters and optimized using the response surface methodology. A reproducible synthesis of more oxygenated apatite with speed of dissolution adaptable to that of the osseous neoformation and allowing a progressive diffusion of oxygenated species (Ca/P = 1.575) is attained. |
| format | Article |
| id | doaj-art-81982a9e427f4e20997c66131f5701e6 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-81982a9e427f4e20997c66131f5701e62025-02-03T06:43:31ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422020-01-01202010.1155/2020/10349591034959Application of Statistical Experimental Design and Surface Plot Technique to Optimize Oxygenated Apatite SynthesisSoumia Belouafa0Hassan Chaair1Khalid Digua2Laboratory of Biomolecules and Organic Synthesis, Faculty of Sciences Ben M’Sik, Hassan II University of Casablanca, Casablanca, MoroccoLaboratory of Process and Environment Engineering, Faculty of Sciences and Technologies Mohammedia, Hassan II University of Casablanca, Casablanca, MoroccoLaboratory of Process and Environment Engineering, Faculty of Sciences and Technologies Mohammedia, Hassan II University of Casablanca, Casablanca, MoroccoThis work deals with oxygenated apatite synthesis from calcium chloride and phosphoric acid using a wet precipitation method. An experimental design is applied to precise the influence of the synthesis parameters (pH of the reaction medium, atomic ratio Ca/P of the reagents, concentration of the calcium solution (Ca2+), temperature of the reaction medium (T), and duration of the reaction (D)) on the chemical composition (Ca/P molar ratio, % O2, and % O22−). An empirical model was developed and validated by applying the ANOVA analysis incorporating the interaction effects of all parameters and optimized using the response surface methodology. A reproducible synthesis of more oxygenated apatite with speed of dissolution adaptable to that of the osseous neoformation and allowing a progressive diffusion of oxygenated species (Ca/P = 1.575) is attained.http://dx.doi.org/10.1155/2020/1034959 |
| spellingShingle | Soumia Belouafa Hassan Chaair Khalid Digua Application of Statistical Experimental Design and Surface Plot Technique to Optimize Oxygenated Apatite Synthesis Advances in Materials Science and Engineering |
| title | Application of Statistical Experimental Design and Surface Plot Technique to Optimize Oxygenated Apatite Synthesis |
| title_full | Application of Statistical Experimental Design and Surface Plot Technique to Optimize Oxygenated Apatite Synthesis |
| title_fullStr | Application of Statistical Experimental Design and Surface Plot Technique to Optimize Oxygenated Apatite Synthesis |
| title_full_unstemmed | Application of Statistical Experimental Design and Surface Plot Technique to Optimize Oxygenated Apatite Synthesis |
| title_short | Application of Statistical Experimental Design and Surface Plot Technique to Optimize Oxygenated Apatite Synthesis |
| title_sort | application of statistical experimental design and surface plot technique to optimize oxygenated apatite synthesis |
| url | http://dx.doi.org/10.1155/2020/1034959 |
| work_keys_str_mv | AT soumiabelouafa applicationofstatisticalexperimentaldesignandsurfaceplottechniquetooptimizeoxygenatedapatitesynthesis AT hassanchaair applicationofstatisticalexperimentaldesignandsurfaceplottechniquetooptimizeoxygenatedapatitesynthesis AT khaliddigua applicationofstatisticalexperimentaldesignandsurfaceplottechniquetooptimizeoxygenatedapatitesynthesis |