Osteoporosis of Crohn’s Disease: A Critical Review
Osteoporosis has long been a recognized complication of Crohn’s disease (CD), with a documented incidence ranging from 31% to 65%. The cause of osteoporosis in Crohn’s patients is likely multifactorial; corticosteroids, inflammatory cytokines, small bowel resection and the resultant calcium and vita...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1996-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1996/720732 |
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| _version_ | 1849410416358195200 |
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| author | Neena S Abraham Richard N Fedorak |
| author_facet | Neena S Abraham Richard N Fedorak |
| author_sort | Neena S Abraham |
| collection | DOAJ |
| description | Osteoporosis has long been a recognized complication of Crohn’s disease (CD), with a documented incidence ranging from 31% to 65%. The cause of osteoporosis in Crohn’s patients is likely multifactorial; corticosteroids, inflammatory cytokines, small bowel resection and the resultant calcium and vitamin D deficiencies, hypogonadism, malnutrition and the cachexia of inflammation all play a role. However, the mechanism responsible for osteoporosis associated with CD remains unclear. Treatment of decreased bone density in CD patients has been limited to calcium and vitamin D replacement. The present understanding of the pathophysiology, mechanism and treatment of osteoporosis in CD is reviewed, with the focus on the role of steroid-induced osteoporosis and the use of bisphosphonates. |
| format | Article |
| id | doaj-art-8196cdb7169e4e108ee587d707f4f495 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-8196cdb7169e4e108ee587d707f4f4952025-08-20T03:35:07ZengWileyCanadian Journal of Gastroenterology0835-79001996-01-0110531732110.1155/1996/720732Osteoporosis of Crohn’s Disease: A Critical ReviewNeena S Abraham0Richard N Fedorak1Division of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaDivision of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaOsteoporosis has long been a recognized complication of Crohn’s disease (CD), with a documented incidence ranging from 31% to 65%. The cause of osteoporosis in Crohn’s patients is likely multifactorial; corticosteroids, inflammatory cytokines, small bowel resection and the resultant calcium and vitamin D deficiencies, hypogonadism, malnutrition and the cachexia of inflammation all play a role. However, the mechanism responsible for osteoporosis associated with CD remains unclear. Treatment of decreased bone density in CD patients has been limited to calcium and vitamin D replacement. The present understanding of the pathophysiology, mechanism and treatment of osteoporosis in CD is reviewed, with the focus on the role of steroid-induced osteoporosis and the use of bisphosphonates.http://dx.doi.org/10.1155/1996/720732 |
| spellingShingle | Neena S Abraham Richard N Fedorak Osteoporosis of Crohn’s Disease: A Critical Review Canadian Journal of Gastroenterology |
| title | Osteoporosis of Crohn’s Disease: A Critical Review |
| title_full | Osteoporosis of Crohn’s Disease: A Critical Review |
| title_fullStr | Osteoporosis of Crohn’s Disease: A Critical Review |
| title_full_unstemmed | Osteoporosis of Crohn’s Disease: A Critical Review |
| title_short | Osteoporosis of Crohn’s Disease: A Critical Review |
| title_sort | osteoporosis of crohn s disease a critical review |
| url | http://dx.doi.org/10.1155/1996/720732 |
| work_keys_str_mv | AT neenasabraham osteoporosisofcrohnsdiseaseacriticalreview AT richardnfedorak osteoporosisofcrohnsdiseaseacriticalreview |