Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization

Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization

IntroductionUlcerative colitis (UC)-related lung injurys is a commonly overlooked extraintestinal manifestation and there are currently no drugs with definitive efficacy available. Cimifugin has been found to inhibit aberrant inflammation and oxidative stress, but its efficacy in UC-related lung inj...

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Bibliographic Details
Main Authors: Guanyuan Wang, Fan Yang, Guodong Zang, Ning Shen, Lina Huang, Zhaotian Ma, Ming Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
cimifugin
ulcerative colitis-related lung injurys
JAK1/STAT1
gut microbiota
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1551892/full
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