Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis
Objective To assess the association of insulin-like growth factor 1 (IGF-1) with the risk of incident ischaemic stroke and outcome after ischaemic stroke.Design A systematic review of primary studies.Setting Hospitals in Western Sweden, Italy, China and Denmark.Methods A search was carried out in el...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e045776.full |
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| author | Jinhui Li Simiao Chen Lan He Yangni Li Weinan Yang Yishu Zhang Lincheng Zhang Yuyan Zhang |
| author_facet | Jinhui Li Simiao Chen Lan He Yangni Li Weinan Yang Yishu Zhang Lincheng Zhang Yuyan Zhang |
| author_sort | Jinhui Li |
| collection | DOAJ |
| description | Objective To assess the association of insulin-like growth factor 1 (IGF-1) with the risk of incident ischaemic stroke and outcome after ischaemic stroke.Design A systematic review of primary studies.Setting Hospitals in Western Sweden, Italy, China and Denmark.Methods A search was carried out in eligible studies in electronic databases (PubMed, Scopus, Embase, China National Knowledge Infrastructure and Web of Science) updated to 29 December 2020. The relevant data were extracted in order to conduct the meta-analysis. Review Manager V.5.2 was used to pool data and calculate the mean difference (MD) and its 95% CI. Heterogeneity, subgroup analysis, sensitivity analysis and publication bias were also performed in this meta-analysis.Results A total of 2277 patients were included in 17 studies. This meta-analysis indicated that higher serum IGF-1 levels were significantly correlated with less risk of ischaemic stroke (MD=−45.32 95% CI –63.70 to –26.94], p < 0.00001, I2=99%) and better improvement of outcome after ischaemic stroke (MD=27.52, 95% CI 3.89 to 51.14, p=0.02, I2=96%). According to subgroup analysis, heterogeneity comes from country, sample size, male and the time from symptom onset to blood collection. Sensitivity analysis showed that there was no significant influence of any individual study on the pooled MD. The effect of high heterogeneity on result credibility was eliminated when four included studies were merged (MD=−30.32, 95% CI −36.52 to –24.11, p< 0.00001, I2=0%). Moreover, no potential publication bias was discovered in this meta-analysis.Conclusion Higher serum IGF-1 was significantly correlated with a lower risk of ischaemic stroke. In view of the high degree of heterogeneity, it may need more studies to confirm the prognostic value of serum IGF-1 levels in ischaemic stroke and explore the sources of heterogeneity. |
| format | Article |
| id | doaj-art-8186d311411745be824411fe163ac348 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-8186d311411745be824411fe163ac3482025-02-01T14:10:09ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2020-045776Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysisJinhui Li0Simiao Chen1Lan He2Yangni Li3Weinan Yang4Yishu Zhang5Lincheng Zhang6Yuyan Zhang7Department of Rehabilitation and Traditional Chinese Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaHeidelberg Institute of Global Health, Heidelberg University, Heidelberg, GermanyThe First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaZhejiang Chinese Medical University, Hangzhou, ChinaZhejiang Chinese Medical University, Hangzhou, ChinaZhejiang Chinese Medical University, Hangzhou, ChinaShanghai Chest Hospital, Shanghai, ChinaZhejiang Chinese Medical University, Hangzhou, ChinaObjective To assess the association of insulin-like growth factor 1 (IGF-1) with the risk of incident ischaemic stroke and outcome after ischaemic stroke.Design A systematic review of primary studies.Setting Hospitals in Western Sweden, Italy, China and Denmark.Methods A search was carried out in eligible studies in electronic databases (PubMed, Scopus, Embase, China National Knowledge Infrastructure and Web of Science) updated to 29 December 2020. The relevant data were extracted in order to conduct the meta-analysis. Review Manager V.5.2 was used to pool data and calculate the mean difference (MD) and its 95% CI. Heterogeneity, subgroup analysis, sensitivity analysis and publication bias were also performed in this meta-analysis.Results A total of 2277 patients were included in 17 studies. This meta-analysis indicated that higher serum IGF-1 levels were significantly correlated with less risk of ischaemic stroke (MD=−45.32 95% CI –63.70 to –26.94], p < 0.00001, I2=99%) and better improvement of outcome after ischaemic stroke (MD=27.52, 95% CI 3.89 to 51.14, p=0.02, I2=96%). According to subgroup analysis, heterogeneity comes from country, sample size, male and the time from symptom onset to blood collection. Sensitivity analysis showed that there was no significant influence of any individual study on the pooled MD. The effect of high heterogeneity on result credibility was eliminated when four included studies were merged (MD=−30.32, 95% CI −36.52 to –24.11, p< 0.00001, I2=0%). Moreover, no potential publication bias was discovered in this meta-analysis.Conclusion Higher serum IGF-1 was significantly correlated with a lower risk of ischaemic stroke. In view of the high degree of heterogeneity, it may need more studies to confirm the prognostic value of serum IGF-1 levels in ischaemic stroke and explore the sources of heterogeneity.https://bmjopen.bmj.com/content/12/6/e045776.full |
| spellingShingle | Jinhui Li Simiao Chen Lan He Yangni Li Weinan Yang Yishu Zhang Lincheng Zhang Yuyan Zhang Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis BMJ Open |
| title | Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis |
| title_full | Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis |
| title_fullStr | Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis |
| title_full_unstemmed | Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis |
| title_short | Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis |
| title_sort | relationship between serum insulin like growth factor 1 levels and ischaemic stroke a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/12/6/e045776.full |
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