Rare and aggressive: A case of embryonal tumor with multilayered rosettes (ETMR) in a young child
Embryonal tumors with multilayered rosettes (ETMR) are rare, highly aggressive brain neoplasms predominantly affecting children under 3 years of age. In the 2021 WHO Classification of Tumors of the Central Nervous System, ETMRs are classified as grade IV tumors, previously considered separate entiti...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-10-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325005874 |
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| author | Oukassem siham Abourak Chaimae Khatibi Wafa Belkouchi Lina El Haddad Siham Allali Nazik Chat Latifa |
| author_facet | Oukassem siham Abourak Chaimae Khatibi Wafa Belkouchi Lina El Haddad Siham Allali Nazik Chat Latifa |
| author_sort | Oukassem siham |
| collection | DOAJ |
| description | Embryonal tumors with multilayered rosettes (ETMR) are rare, highly aggressive brain neoplasms predominantly affecting children under 3 years of age. In the 2021 WHO Classification of Tumors of the Central Nervous System, ETMRs are classified as grade IV tumors, previously considered separate entities such as embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL). We report a 13-month-old girl who presented with afebrile seizures, left hemiparesis, and status epilepticus. Neuroimaging revealed a right fronto-parieto-temporal mass with typical features of ETMR, confirmed by stereotactic biopsy. Despite supportive care and preparation for surgery, the patient's condition deteriorated rapidly, and she passed away 15 days after admission. This case highlights the typical presentation, imaging characteristics, and poor prognosis of ETMR, emphasizing the importance of early recognition and molecular testing in enhancing diagnosis and treatment strategies |
| format | Article |
| id | doaj-art-8185fb684c724dd08dab95a55ee2b5cd |
| institution | DOAJ |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-8185fb684c724dd08dab95a55ee2b5cd2025-08-20T03:11:46ZengElsevierRadiology Case Reports1930-04332025-10-0120104890489410.1016/j.radcr.2025.06.042Rare and aggressive: A case of embryonal tumor with multilayered rosettes (ETMR) in a young childOukassem siham0Abourak Chaimae1Khatibi Wafa2Belkouchi Lina3El Haddad Siham4Allali Nazik5Chat Latifa6Corresponding author.; Department of Radiology, Mother-Child, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, MoroccoDepartment of Radiology, Mother-Child, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, MoroccoDepartment of Radiology, Mother-Child, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, MoroccoDepartment of Radiology, Mother-Child, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, MoroccoDepartment of Radiology, Mother-Child, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, MoroccoDepartment of Radiology, Mother-Child, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, MoroccoDepartment of Radiology, Mother-Child, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, MoroccoEmbryonal tumors with multilayered rosettes (ETMR) are rare, highly aggressive brain neoplasms predominantly affecting children under 3 years of age. In the 2021 WHO Classification of Tumors of the Central Nervous System, ETMRs are classified as grade IV tumors, previously considered separate entities such as embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL). We report a 13-month-old girl who presented with afebrile seizures, left hemiparesis, and status epilepticus. Neuroimaging revealed a right fronto-parieto-temporal mass with typical features of ETMR, confirmed by stereotactic biopsy. Despite supportive care and preparation for surgery, the patient's condition deteriorated rapidly, and she passed away 15 days after admission. This case highlights the typical presentation, imaging characteristics, and poor prognosis of ETMR, emphasizing the importance of early recognition and molecular testing in enhancing diagnosis and treatment strategieshttp://www.sciencedirect.com/science/article/pii/S1930043325005874ETMRMRIPediatric brain tumorPrognosis |
| spellingShingle | Oukassem siham Abourak Chaimae Khatibi Wafa Belkouchi Lina El Haddad Siham Allali Nazik Chat Latifa Rare and aggressive: A case of embryonal tumor with multilayered rosettes (ETMR) in a young child Radiology Case Reports ETMR MRI Pediatric brain tumor Prognosis |
| title | Rare and aggressive: A case of embryonal tumor with multilayered rosettes (ETMR) in a young child |
| title_full | Rare and aggressive: A case of embryonal tumor with multilayered rosettes (ETMR) in a young child |
| title_fullStr | Rare and aggressive: A case of embryonal tumor with multilayered rosettes (ETMR) in a young child |
| title_full_unstemmed | Rare and aggressive: A case of embryonal tumor with multilayered rosettes (ETMR) in a young child |
| title_short | Rare and aggressive: A case of embryonal tumor with multilayered rosettes (ETMR) in a young child |
| title_sort | rare and aggressive a case of embryonal tumor with multilayered rosettes etmr in a young child |
| topic | ETMR MRI Pediatric brain tumor Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325005874 |
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