Efficacy and safety of ureterorenoscopy in the elderly: A systematic review axnd meta-analysis.
<h4>Objective</h4>Ureterorenoscopy (URS) is a common procedure performed for renal or upper ureteric stones. Nevertheless, the efficacy and safety of URS in the elderly is unclear. We conducted the first meta-analysis of literature comparing outcomes of URS between elderly and non-elderl...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0323237 |
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| author | Minna Shen Minqiang Shen |
| author_facet | Minna Shen Minqiang Shen |
| author_sort | Minna Shen |
| collection | DOAJ |
| description | <h4>Objective</h4>Ureterorenoscopy (URS) is a common procedure performed for renal or upper ureteric stones. Nevertheless, the efficacy and safety of URS in the elderly is unclear. We conducted the first meta-analysis of literature comparing outcomes of URS between elderly and non-elderly patients.<h4>Methods</h4>Embase, PubMed, Web of Science, and Scopus databases were searched for studies relevant to the review. The last date was 2nd September 2024. The elderly were defined as ≥ 65 or 60 years of age. Outcomes compared were stone-free rates (SFR), complications, and length of hospital stay (LOS).<h4>Results</h4>Nine studies met the inclusion criteria. Pooled analysis showed that there was no difference in SFR between elderly and non-elderly groups after URS (OR: 0.96 95% CI: 0.81, 1.14 I2 = 3%). Meta-analysis failed to show any statistical significant in all complication rates (OR: 1.04 95% CI: 0.77, 1.40 I2 = 51%) as well as infectious (OR: 1.27 95% CI: 0.84, 1.92 I2 = 0%), medical (OR: 2.01 95% CI: 0.23, 17.57 I2 = 93%), surgical (OR: 1.18 95% CI: 0.68, 2.03 I2 = 0%) or Clavein Dindo grade ≥2 (OR: 1.02 95% CI: 0.60, 1.75 I2 = 0%) complications between elderly and non-elderly groups. Meta-analysis showed that the elderly had significantly longer LOS as compared to non-elderly patients (MD: 0.75 95% CI: 0.05, 1.45 I2 = 90%).<h4>Conclusions</h4>URS seems to efficacious and safe in the elderly. Patients ≥60 or 65 years of age have similar SFR and complication rates as younger patients. However, LOS may be increased in the elderly. More robust studies taking into account baseline characteristics and importantly presenting rates are needed to validate the current results. |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-81853cd8a4634b26b76493a8fb4358382025-08-20T02:38:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01205e032323710.1371/journal.pone.0323237Efficacy and safety of ureterorenoscopy in the elderly: A systematic review axnd meta-analysis.Minna ShenMinqiang Shen<h4>Objective</h4>Ureterorenoscopy (URS) is a common procedure performed for renal or upper ureteric stones. Nevertheless, the efficacy and safety of URS in the elderly is unclear. We conducted the first meta-analysis of literature comparing outcomes of URS between elderly and non-elderly patients.<h4>Methods</h4>Embase, PubMed, Web of Science, and Scopus databases were searched for studies relevant to the review. The last date was 2nd September 2024. The elderly were defined as ≥ 65 or 60 years of age. Outcomes compared were stone-free rates (SFR), complications, and length of hospital stay (LOS).<h4>Results</h4>Nine studies met the inclusion criteria. Pooled analysis showed that there was no difference in SFR between elderly and non-elderly groups after URS (OR: 0.96 95% CI: 0.81, 1.14 I2 = 3%). Meta-analysis failed to show any statistical significant in all complication rates (OR: 1.04 95% CI: 0.77, 1.40 I2 = 51%) as well as infectious (OR: 1.27 95% CI: 0.84, 1.92 I2 = 0%), medical (OR: 2.01 95% CI: 0.23, 17.57 I2 = 93%), surgical (OR: 1.18 95% CI: 0.68, 2.03 I2 = 0%) or Clavein Dindo grade ≥2 (OR: 1.02 95% CI: 0.60, 1.75 I2 = 0%) complications between elderly and non-elderly groups. Meta-analysis showed that the elderly had significantly longer LOS as compared to non-elderly patients (MD: 0.75 95% CI: 0.05, 1.45 I2 = 90%).<h4>Conclusions</h4>URS seems to efficacious and safe in the elderly. Patients ≥60 or 65 years of age have similar SFR and complication rates as younger patients. However, LOS may be increased in the elderly. More robust studies taking into account baseline characteristics and importantly presenting rates are needed to validate the current results.https://doi.org/10.1371/journal.pone.0323237 |
| spellingShingle | Minna Shen Minqiang Shen Efficacy and safety of ureterorenoscopy in the elderly: A systematic review axnd meta-analysis. PLoS ONE |
| title | Efficacy and safety of ureterorenoscopy in the elderly: A systematic review axnd meta-analysis. |
| title_full | Efficacy and safety of ureterorenoscopy in the elderly: A systematic review axnd meta-analysis. |
| title_fullStr | Efficacy and safety of ureterorenoscopy in the elderly: A systematic review axnd meta-analysis. |
| title_full_unstemmed | Efficacy and safety of ureterorenoscopy in the elderly: A systematic review axnd meta-analysis. |
| title_short | Efficacy and safety of ureterorenoscopy in the elderly: A systematic review axnd meta-analysis. |
| title_sort | efficacy and safety of ureterorenoscopy in the elderly a systematic review axnd meta analysis |
| url | https://doi.org/10.1371/journal.pone.0323237 |
| work_keys_str_mv | AT minnashen efficacyandsafetyofureterorenoscopyintheelderlyasystematicreviewaxndmetaanalysis AT minqiangshen efficacyandsafetyofureterorenoscopyintheelderlyasystematicreviewaxndmetaanalysis |