Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.

Recombinant adenovirus serotype 5 (Ad5) vectors represent one of the most efficient gene delivery vectors in life sciences. However, Ad5 is dependent on expression of the coxsackievirus-adenovirus-receptor (CAR) on the surface of target cell for efficient transduction, which limits it's utility...

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Main Authors: Di Yu, Chuan Jin, Mohanraj Ramachandran, Jing Xu, Berith Nilsson, Olle Korsgren, Katarina Le Blanc, Lene Uhrbom, Karin Forsberg-Nilsson, Bengt Westermark, Rachel Adamson, Norman Maitland, Xiaolong Fan, Magnus Essand
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054952&type=printable
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author Di Yu
Chuan Jin
Mohanraj Ramachandran
Jing Xu
Berith Nilsson
Olle Korsgren
Katarina Le Blanc
Lene Uhrbom
Karin Forsberg-Nilsson
Bengt Westermark
Rachel Adamson
Norman Maitland
Xiaolong Fan
Magnus Essand
author_facet Di Yu
Chuan Jin
Mohanraj Ramachandran
Jing Xu
Berith Nilsson
Olle Korsgren
Katarina Le Blanc
Lene Uhrbom
Karin Forsberg-Nilsson
Bengt Westermark
Rachel Adamson
Norman Maitland
Xiaolong Fan
Magnus Essand
author_sort Di Yu
collection DOAJ
description Recombinant adenovirus serotype 5 (Ad5) vectors represent one of the most efficient gene delivery vectors in life sciences. However, Ad5 is dependent on expression of the coxsackievirus-adenovirus-receptor (CAR) on the surface of target cell for efficient transduction, which limits it's utility for certain cell types. Herein we present a new vector, Ad5PTDf35, which is an Ad5 vector having serotype 35 fiber-specificity and Tat-PTD hexon-modification. This vector shows dramatically increased transduction capacity of primary human cell cultures including T cells, monocytes, macrophages, dendritic cells, pancreatic islets and exocrine cells, mesenchymal stem cells and tumor initiating cells. Biodistribution in mice following systemic administration (tail-vein injection) show significantly reduced uptake in the liver and spleen of Ad5PTDf35 compared to unmodified Ad5. Therefore, replication-competent viruses with these modifications may be further developed as oncolytic agents for cancer therapy. User-friendly backbone plasmids containing these modifications were developed for compatibility to the AdEasy-system to facilitate the development of surface-modified adenoviruses for gene delivery to difficult-to-transduce cells in basic, pre-clinical and clinical research.
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institution Kabale University
issn 1932-6203
language English
publishDate 2013-01-01
publisher Public Library of Science (PLoS)
record_format Article
series PLoS ONE
spelling doaj-art-81845b54f6f045ed86a4443cbfdc29702025-08-20T03:25:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5495210.1371/journal.pone.0054952Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.Di YuChuan JinMohanraj RamachandranJing XuBerith NilssonOlle KorsgrenKatarina Le BlancLene UhrbomKarin Forsberg-NilssonBengt WestermarkRachel AdamsonNorman MaitlandXiaolong FanMagnus EssandRecombinant adenovirus serotype 5 (Ad5) vectors represent one of the most efficient gene delivery vectors in life sciences. However, Ad5 is dependent on expression of the coxsackievirus-adenovirus-receptor (CAR) on the surface of target cell for efficient transduction, which limits it's utility for certain cell types. Herein we present a new vector, Ad5PTDf35, which is an Ad5 vector having serotype 35 fiber-specificity and Tat-PTD hexon-modification. This vector shows dramatically increased transduction capacity of primary human cell cultures including T cells, monocytes, macrophages, dendritic cells, pancreatic islets and exocrine cells, mesenchymal stem cells and tumor initiating cells. Biodistribution in mice following systemic administration (tail-vein injection) show significantly reduced uptake in the liver and spleen of Ad5PTDf35 compared to unmodified Ad5. Therefore, replication-competent viruses with these modifications may be further developed as oncolytic agents for cancer therapy. User-friendly backbone plasmids containing these modifications were developed for compatibility to the AdEasy-system to facilitate the development of surface-modified adenoviruses for gene delivery to difficult-to-transduce cells in basic, pre-clinical and clinical research.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054952&type=printable
spellingShingle Di Yu
Chuan Jin
Mohanraj Ramachandran
Jing Xu
Berith Nilsson
Olle Korsgren
Katarina Le Blanc
Lene Uhrbom
Karin Forsberg-Nilsson
Bengt Westermark
Rachel Adamson
Norman Maitland
Xiaolong Fan
Magnus Essand
Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.
PLoS ONE
title Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.
title_full Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.
title_fullStr Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.
title_full_unstemmed Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.
title_short Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.
title_sort adenovirus serotype 5 vectors with tat ptd modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures
url https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054952&type=printable
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