Addressing the silent threat: managing invasive Candida infections in hospitalized newborns
Invasive fungal infections (IFIs) remain an important problem for hospitalized newborn infants receiving intensive care, given their substantial morbidity and mortality. Candida species (Candida spp.) are the major fungal pathogens, which cause the so-called invasive Candida infections (ICIs). Of th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1613832/full |
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| author | Deshuang Zhang Deshuang Zhang Dongke Xie Haokun Yuan Na He Wenbin Dong Xiaoping Lei |
| author_facet | Deshuang Zhang Deshuang Zhang Dongke Xie Haokun Yuan Na He Wenbin Dong Xiaoping Lei |
| author_sort | Deshuang Zhang |
| collection | DOAJ |
| description | Invasive fungal infections (IFIs) remain an important problem for hospitalized newborn infants receiving intensive care, given their substantial morbidity and mortality. Candida species (Candida spp.) are the major fungal pathogens, which cause the so-called invasive Candida infections (ICIs). Of these, Candida albicans is the most commonly isolated species, followed by Candida parapsilosis. Other identified Candida spp. include Candida glabrata, Candida tropicalis, Candida krusei, etc. However, an increasing shift in the epidemiology of ICIs worldwide has been described, non-albicans Candida (NAC) spp. ICIs pose a growing threat to neonates. Herein, we examine the epidemiology of Candida spp. infections, patterns of antifungal resistance, risk factors, prevention strategies, clinical outcomes, and treatment recommendations for ICIs in hospitalized newborn infants. This review aims to provide a thorough understanding of the current evidence on ICIs to better inform targeted prevention strategies and improved treatments to reduce neonatal morbidity and mortality. |
| format | Article |
| id | doaj-art-817d1a94f8cc4334a0efced710542bba |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-817d1a94f8cc4334a0efced710542bba2025-08-20T03:50:53ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-07-011310.3389/fped.2025.16138321613832Addressing the silent threat: managing invasive Candida infections in hospitalized newbornsDeshuang Zhang0Deshuang Zhang1Dongke Xie2Haokun Yuan3Na He4Wenbin Dong5Xiaoping Lei6Department of Neonatology, Children’s Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Pediatric Surgery, Children’s Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Neonatology, Children’s Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Neonatology, Children’s Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Neonatology, Children’s Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Neonatology, Children’s Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaInvasive fungal infections (IFIs) remain an important problem for hospitalized newborn infants receiving intensive care, given their substantial morbidity and mortality. Candida species (Candida spp.) are the major fungal pathogens, which cause the so-called invasive Candida infections (ICIs). Of these, Candida albicans is the most commonly isolated species, followed by Candida parapsilosis. Other identified Candida spp. include Candida glabrata, Candida tropicalis, Candida krusei, etc. However, an increasing shift in the epidemiology of ICIs worldwide has been described, non-albicans Candida (NAC) spp. ICIs pose a growing threat to neonates. Herein, we examine the epidemiology of Candida spp. infections, patterns of antifungal resistance, risk factors, prevention strategies, clinical outcomes, and treatment recommendations for ICIs in hospitalized newborn infants. This review aims to provide a thorough understanding of the current evidence on ICIs to better inform targeted prevention strategies and improved treatments to reduce neonatal morbidity and mortality.https://www.frontiersin.org/articles/10.3389/fped.2025.1613832/fullantifungal resistanceinvasive Candida infections (ICIs)newborn infantspathogensprevention strategiesrisk factors |
| spellingShingle | Deshuang Zhang Deshuang Zhang Dongke Xie Haokun Yuan Na He Wenbin Dong Xiaoping Lei Addressing the silent threat: managing invasive Candida infections in hospitalized newborns Frontiers in Pediatrics antifungal resistance invasive Candida infections (ICIs) newborn infants pathogens prevention strategies risk factors |
| title | Addressing the silent threat: managing invasive Candida infections in hospitalized newborns |
| title_full | Addressing the silent threat: managing invasive Candida infections in hospitalized newborns |
| title_fullStr | Addressing the silent threat: managing invasive Candida infections in hospitalized newborns |
| title_full_unstemmed | Addressing the silent threat: managing invasive Candida infections in hospitalized newborns |
| title_short | Addressing the silent threat: managing invasive Candida infections in hospitalized newborns |
| title_sort | addressing the silent threat managing invasive candida infections in hospitalized newborns |
| topic | antifungal resistance invasive Candida infections (ICIs) newborn infants pathogens prevention strategies risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1613832/full |
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