Prebiotic- and Panthenol-Containing Multipurpose Healing Dermocosmetics Post-Cryotherapy for Actinic Keratoses: Results of a Randomized Controlled Trial
Introduction: Actinic keratosis (AK) is a precancerous skin lesion that can progress to keratinocyte carcinoma. Objective: The objective of the study was to evaluate the efficacy of a dermocosmetic (DC) formulation containing prebiotic active ingredients (Aqua Posae Filiformis, a complex made of...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mattioli1885
2025-01-01
|
| Series: | Dermatology Practical & Conceptual |
| Subjects: | |
| Online Access: | https://dpcj.org/index.php/dpc/article/view/4905 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540725629157376 |
|---|---|
| author | Cesare Ariasi Carola Romanò Cesare Tomasi Simone Soglia Gaetano Licata Luca Rubelli Piergiacomo Calzavara Pinton Marina Venturini Mariachiara Arisi |
| author_facet | Cesare Ariasi Carola Romanò Cesare Tomasi Simone Soglia Gaetano Licata Luca Rubelli Piergiacomo Calzavara Pinton Marina Venturini Mariachiara Arisi |
| author_sort | Cesare Ariasi |
| collection | DOAJ |
| description |
Introduction: Actinic keratosis (AK) is a precancerous skin lesion that can progress to keratinocyte carcinoma.
Objective: The objective of the study was to evaluate the efficacy of a dermocosmetic (DC) formulation containing prebiotic active ingredients (Aqua Posae Filiformis, a complex made of ferments, sugars, plant extracts, panthenol, madecassoside, and zinc) on healing time and local skin reactions (LSR) following cryotherapy of AKs and to compare the application of DC aand boric acid 3% solution soaks (BA) vs. BA alone.
Methods: Seventy-five adult patients presenting with a maximum of 5 isolated AKS on the face and/or scalp and who underwent cryotherapy (T0) were enrolled. Post-treatment, patients initiated the application of BA only or BA followed by DC once daily for 30 days (unblinded 1:1 randomization). The evaluation of efficacy in healing time and cosmetic outcomes was assessed 30 days post-treatment (T2); LSR was evaluated 3 days post-treatment (T1).
Results: There was a gain of 4.5 days (40%) in healing time in the BA+DC group compared to the BA group, with a median time of 7 days versus 11.5 days (P<0.0005). Additionally, 50% of lesions in complete response had an excellent cosmetic outcome with BA+DC vs. 20% with BA only. The majority of patients treated with BA+DC had mild LSR vs. moderate LSR with BA, with a median value of 2 vs 3, respectively (P<0.0001).
Conclusion: The addition of a prebiotic DC significantly reduced healing time, improved cosmetic outcomes, and minimized LSR post-cryotherapy. No adverse events were reported with this treatment.
|
| format | Article |
| id | doaj-art-817a680808f24e0b881800b0b8e4b026 |
| institution | Kabale University |
| issn | 2160-9381 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj-art-817a680808f24e0b881800b0b8e4b0262025-02-04T15:41:28ZengMattioli1885Dermatology Practical & Conceptual2160-93812025-01-0115110.5826/dpc.1501a4905Prebiotic- and Panthenol-Containing Multipurpose Healing Dermocosmetics Post-Cryotherapy for Actinic Keratoses: Results of a Randomized Controlled TrialCesare Ariasi0Carola Romanò1Cesare Tomasi2Simone Soglia3Gaetano Licata4Luca Rubelli5Piergiacomo Calzavara Pinton6Marina Venturini7Mariachiara Arisi8Department of Dermatology, University of Brescia, Brescia, ItalyDepartment of Dermatology, University of Brescia, Brescia, ItalyDepartment of Dermatology, University of Brescia, Brescia, ItalyDepartment of Dermatology, University of Brescia, Brescia, ItalyDepartment of Dermatology, San Antonio Abate Hospital, Trapani, ItalyDepartment of Dermatology, University of Brescia, Brescia, ItalyDepartment of Dermatology, University of Brescia, Brescia, ItalyDepartment of Dermatology, University of Brescia, Brescia, ItalyDepartment of Dermatology, University of Brescia, Brescia, Italy Introduction: Actinic keratosis (AK) is a precancerous skin lesion that can progress to keratinocyte carcinoma. Objective: The objective of the study was to evaluate the efficacy of a dermocosmetic (DC) formulation containing prebiotic active ingredients (Aqua Posae Filiformis, a complex made of ferments, sugars, plant extracts, panthenol, madecassoside, and zinc) on healing time and local skin reactions (LSR) following cryotherapy of AKs and to compare the application of DC aand boric acid 3% solution soaks (BA) vs. BA alone. Methods: Seventy-five adult patients presenting with a maximum of 5 isolated AKS on the face and/or scalp and who underwent cryotherapy (T0) were enrolled. Post-treatment, patients initiated the application of BA only or BA followed by DC once daily for 30 days (unblinded 1:1 randomization). The evaluation of efficacy in healing time and cosmetic outcomes was assessed 30 days post-treatment (T2); LSR was evaluated 3 days post-treatment (T1). Results: There was a gain of 4.5 days (40%) in healing time in the BA+DC group compared to the BA group, with a median time of 7 days versus 11.5 days (P<0.0005). Additionally, 50% of lesions in complete response had an excellent cosmetic outcome with BA+DC vs. 20% with BA only. The majority of patients treated with BA+DC had mild LSR vs. moderate LSR with BA, with a median value of 2 vs 3, respectively (P<0.0001). Conclusion: The addition of a prebiotic DC significantly reduced healing time, improved cosmetic outcomes, and minimized LSR post-cryotherapy. No adverse events were reported with this treatment. https://dpcj.org/index.php/dpc/article/view/4905Dermocosmetic formulationLocal skin reactions CryotherapyActinic keratosis |
| spellingShingle | Cesare Ariasi Carola Romanò Cesare Tomasi Simone Soglia Gaetano Licata Luca Rubelli Piergiacomo Calzavara Pinton Marina Venturini Mariachiara Arisi Prebiotic- and Panthenol-Containing Multipurpose Healing Dermocosmetics Post-Cryotherapy for Actinic Keratoses: Results of a Randomized Controlled Trial Dermatology Practical & Conceptual Dermocosmetic formulation Local skin reactions Cryotherapy Actinic keratosis |
| title | Prebiotic- and Panthenol-Containing Multipurpose Healing Dermocosmetics Post-Cryotherapy for Actinic Keratoses: Results of a Randomized Controlled Trial |
| title_full | Prebiotic- and Panthenol-Containing Multipurpose Healing Dermocosmetics Post-Cryotherapy for Actinic Keratoses: Results of a Randomized Controlled Trial |
| title_fullStr | Prebiotic- and Panthenol-Containing Multipurpose Healing Dermocosmetics Post-Cryotherapy for Actinic Keratoses: Results of a Randomized Controlled Trial |
| title_full_unstemmed | Prebiotic- and Panthenol-Containing Multipurpose Healing Dermocosmetics Post-Cryotherapy for Actinic Keratoses: Results of a Randomized Controlled Trial |
| title_short | Prebiotic- and Panthenol-Containing Multipurpose Healing Dermocosmetics Post-Cryotherapy for Actinic Keratoses: Results of a Randomized Controlled Trial |
| title_sort | prebiotic and panthenol containing multipurpose healing dermocosmetics post cryotherapy for actinic keratoses results of a randomized controlled trial |
| topic | Dermocosmetic formulation Local skin reactions Cryotherapy Actinic keratosis |
| url | https://dpcj.org/index.php/dpc/article/view/4905 |
| work_keys_str_mv | AT cesareariasi prebioticandpanthenolcontainingmultipurposehealingdermocosmeticspostcryotherapyforactinickeratosesresultsofarandomizedcontrolledtrial AT carolaromano prebioticandpanthenolcontainingmultipurposehealingdermocosmeticspostcryotherapyforactinickeratosesresultsofarandomizedcontrolledtrial AT cesaretomasi prebioticandpanthenolcontainingmultipurposehealingdermocosmeticspostcryotherapyforactinickeratosesresultsofarandomizedcontrolledtrial AT simonesoglia prebioticandpanthenolcontainingmultipurposehealingdermocosmeticspostcryotherapyforactinickeratosesresultsofarandomizedcontrolledtrial AT gaetanolicata prebioticandpanthenolcontainingmultipurposehealingdermocosmeticspostcryotherapyforactinickeratosesresultsofarandomizedcontrolledtrial AT lucarubelli prebioticandpanthenolcontainingmultipurposehealingdermocosmeticspostcryotherapyforactinickeratosesresultsofarandomizedcontrolledtrial AT piergiacomocalzavarapinton prebioticandpanthenolcontainingmultipurposehealingdermocosmeticspostcryotherapyforactinickeratosesresultsofarandomizedcontrolledtrial AT marinaventurini prebioticandpanthenolcontainingmultipurposehealingdermocosmeticspostcryotherapyforactinickeratosesresultsofarandomizedcontrolledtrial AT mariachiaraarisi prebioticandpanthenolcontainingmultipurposehealingdermocosmeticspostcryotherapyforactinickeratosesresultsofarandomizedcontrolledtrial |