Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function
Polarity refers to the asymmetric distribution of different cellular components within a cell and is central to many cell functions. In T-cells, polarity regulates the activation, migration, and effector function of cytotoxic T-cells (CTLs) during an immune response. The regulation of asymmetric cel...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/417485 |
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| author | Ivan Fung Sarah M. Russell Jane Oliaro |
| author_facet | Ivan Fung Sarah M. Russell Jane Oliaro |
| author_sort | Ivan Fung |
| collection | DOAJ |
| description | Polarity refers to the asymmetric distribution of different cellular components within a cell and is central to many cell functions. In T-cells, polarity regulates the activation, migration, and effector function of cytotoxic T-cells (CTLs) during an immune response. The regulation of asymmetric cell division by polarity proteins may also dictate CTL effector and memory differentiation following antigen presentation. Small GTPases, along with their associated polarity and adaptor proteins, are critical for mediating the polarity changes necessary for T-cell activation and function, and in turn, are regulated by guanine exchange factors (GEFS) and GTPase activating proteins (GAPS). For example, a novel GEF, dedicator of cytokinesis 8 (DOCK8) was recently identified as a regulator of immune cell function and mutations in DOCK8 have been detected in patients with severe combined immunodeficiency. Both B and T-cells from DOCK8 mutant mice form defective immunological synapses and have abnormal functions, in addition to impaired immune memory development. This paper will discuss the interplay between polarity proteins and GTPases, and their role in T-cell function. |
| format | Article |
| id | doaj-art-81768a5efd2d4b3f8519df9d833fc819 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-81768a5efd2d4b3f8519df9d833fc8192025-08-20T03:35:07ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/417485417485Interplay of Polarity Proteins and GTPases in T-Lymphocyte FunctionIvan Fung0Sarah M. Russell1Jane Oliaro2Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, AustraliaCancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, AustraliaCancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, AustraliaPolarity refers to the asymmetric distribution of different cellular components within a cell and is central to many cell functions. In T-cells, polarity regulates the activation, migration, and effector function of cytotoxic T-cells (CTLs) during an immune response. The regulation of asymmetric cell division by polarity proteins may also dictate CTL effector and memory differentiation following antigen presentation. Small GTPases, along with their associated polarity and adaptor proteins, are critical for mediating the polarity changes necessary for T-cell activation and function, and in turn, are regulated by guanine exchange factors (GEFS) and GTPase activating proteins (GAPS). For example, a novel GEF, dedicator of cytokinesis 8 (DOCK8) was recently identified as a regulator of immune cell function and mutations in DOCK8 have been detected in patients with severe combined immunodeficiency. Both B and T-cells from DOCK8 mutant mice form defective immunological synapses and have abnormal functions, in addition to impaired immune memory development. This paper will discuss the interplay between polarity proteins and GTPases, and their role in T-cell function.http://dx.doi.org/10.1155/2012/417485 |
| spellingShingle | Ivan Fung Sarah M. Russell Jane Oliaro Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function Clinical and Developmental Immunology |
| title | Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function |
| title_full | Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function |
| title_fullStr | Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function |
| title_full_unstemmed | Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function |
| title_short | Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function |
| title_sort | interplay of polarity proteins and gtpases in t lymphocyte function |
| url | http://dx.doi.org/10.1155/2012/417485 |
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