Advanced Glycation End Products in Disease Development and Potential Interventions
Advanced glycation end products (AGEs) are a group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs can be generated in the body or introduced through dietary sources and smoking. Recent clinical and animal studies have highligh...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/14/4/492 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850144719435202560 |
|---|---|
| author | Yihan Zhang Zhen Zhang Chuyue Tu Xu Chen Ruikun He |
| author_facet | Yihan Zhang Zhen Zhang Chuyue Tu Xu Chen Ruikun He |
| author_sort | Yihan Zhang |
| collection | DOAJ |
| description | Advanced glycation end products (AGEs) are a group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs can be generated in the body or introduced through dietary sources and smoking. Recent clinical and animal studies have highlighted the significant role of AGEs in various health conditions. These compounds accumulate in nearly all mammalian tissues and are associated with a range of diseases, including diabetes and its complications, cardiovascular disease, and neurodegeneration. This review summarizes the major diseases linked to AGE accumulation, presenting both clinical and experimental evidence. The pathologies induced by AGEs share common mechanisms across different organs, primarily involving oxidative stress, chronic inflammation, and direct protein cross-linking. Interventions targeting AGE-related diseases focus on inhibiting AGE formation using synthetic or natural antioxidants, as well as reducing dietary AGE intake through lifestyle modifications. AGEs are recognized as significant risk factors that impact health and accelerate aging, particularly in individuals with hyperglycemia. Monitoring AGE level and implementing nutritional interventions can help maintain overall health and reduce the risk of AGE-related complications. |
| format | Article |
| id | doaj-art-81732eefdc3e4c4bb4774fab332a59ae |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-81732eefdc3e4c4bb4774fab332a59ae2025-08-20T02:28:16ZengMDPI AGAntioxidants2076-39212025-04-0114449210.3390/antiox14040492Advanced Glycation End Products in Disease Development and Potential InterventionsYihan Zhang0Zhen Zhang1Chuyue Tu2Xu Chen3Ruikun He4School of Biology and Biological Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu District, Guangzhou 510006, ChinaSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu District, Guangzhou 510006, ChinaBYHEALTH Institute of Nutrition & Health, No. 916, Huangpu Avenue East, Huangpu District, Guangzhou 510799, ChinaBYHEALTH Institute of Nutrition & Health, No. 916, Huangpu Avenue East, Huangpu District, Guangzhou 510799, ChinaBYHEALTH Institute of Nutrition & Health, No. 916, Huangpu Avenue East, Huangpu District, Guangzhou 510799, ChinaAdvanced glycation end products (AGEs) are a group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs can be generated in the body or introduced through dietary sources and smoking. Recent clinical and animal studies have highlighted the significant role of AGEs in various health conditions. These compounds accumulate in nearly all mammalian tissues and are associated with a range of diseases, including diabetes and its complications, cardiovascular disease, and neurodegeneration. This review summarizes the major diseases linked to AGE accumulation, presenting both clinical and experimental evidence. The pathologies induced by AGEs share common mechanisms across different organs, primarily involving oxidative stress, chronic inflammation, and direct protein cross-linking. Interventions targeting AGE-related diseases focus on inhibiting AGE formation using synthetic or natural antioxidants, as well as reducing dietary AGE intake through lifestyle modifications. AGEs are recognized as significant risk factors that impact health and accelerate aging, particularly in individuals with hyperglycemia. Monitoring AGE level and implementing nutritional interventions can help maintain overall health and reduce the risk of AGE-related complications.https://www.mdpi.com/2076-3921/14/4/492advanced glycation end productschronic diseasesinterventionnatural products |
| spellingShingle | Yihan Zhang Zhen Zhang Chuyue Tu Xu Chen Ruikun He Advanced Glycation End Products in Disease Development and Potential Interventions Antioxidants advanced glycation end products chronic diseases intervention natural products |
| title | Advanced Glycation End Products in Disease Development and Potential Interventions |
| title_full | Advanced Glycation End Products in Disease Development and Potential Interventions |
| title_fullStr | Advanced Glycation End Products in Disease Development and Potential Interventions |
| title_full_unstemmed | Advanced Glycation End Products in Disease Development and Potential Interventions |
| title_short | Advanced Glycation End Products in Disease Development and Potential Interventions |
| title_sort | advanced glycation end products in disease development and potential interventions |
| topic | advanced glycation end products chronic diseases intervention natural products |
| url | https://www.mdpi.com/2076-3921/14/4/492 |
| work_keys_str_mv | AT yihanzhang advancedglycationendproductsindiseasedevelopmentandpotentialinterventions AT zhenzhang advancedglycationendproductsindiseasedevelopmentandpotentialinterventions AT chuyuetu advancedglycationendproductsindiseasedevelopmentandpotentialinterventions AT xuchen advancedglycationendproductsindiseasedevelopmentandpotentialinterventions AT ruikunhe advancedglycationendproductsindiseasedevelopmentandpotentialinterventions |