The effects of the Wnt/β-catenin signaling pathway on the in vitro differentiation of rat BMSCs into leydig cells

The effects of the Wnt/β-catenin signaling pathway on the in vitro differentiation of rat BMSCs into leydig cells

Abstract Late-onset hypogonadism (LOH) refers to sexual and non-sexual symptoms in men caused by age-related decreases in circulating testosterone. Leydig cells (LCs) transplantation is considered to be one of a viable approach for LOH therapy, but the limited source of LCs limits the application of...

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Bibliographic Details
Main Authors: Pengyu Yan, Yaxiong Guo, Shoaib Muhammad, Jinxiong Zhu, Yuxiang Liu, Chun Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Late-onset hypogonadism
Bone mesenchymal stem cell
Leydig cell
Wnt/β-catenin
Testosterone
Online Access:https://doi.org/10.1038/s41598-025-85674-z
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