Hexagonal metal complex based mechanically robust transparent ultrathin gold µECoG for electro-optical neural interfaces
Abstract Transparent electro-optical neural interfacing technologies offer simultaneous high-spatial-resolution microscopic imaging, and high-temporal-resolution electrical recording and stimulation. However, fabricating transparent, flexible, and mechanically robust neural electrodes with high elec...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
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| Series: | npj Flexible Electronics |
| Online Access: | https://doi.org/10.1038/s41528-025-00403-w |
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| Summary: | Abstract Transparent electro-optical neural interfacing technologies offer simultaneous high-spatial-resolution microscopic imaging, and high-temporal-resolution electrical recording and stimulation. However, fabricating transparent, flexible, and mechanically robust neural electrodes with high electrochemical performance remains challenging. In this study, we fabricated transparent (72.7% at 570 nm), mechanically robust (0.05% resistance change after 50k bending cycles) ultrathin Au microelectrodes for micro-electrocorticography (µECoG) using a hexadentate metal-polymer ligand bonding with an EDTA/PSS seed layer. These transparent µECoG arrays, fabricated with biocompatible gold, exhibit excellent electrochemical properties (0.73 Ω·cm2) for neural recording and stimulation with long-term stability. We recorded brain surface waves in vivo, maintaining a low baseline noise and a high signal-to-noise ratio during acute and two-week recordings. In addition, we successfully performed optogenetic modulation without light-induced artifacts at 7.32 mW/mm2 laser power density. This approach shows great potential for scalable, implantable neural electrodes and wearable optoelectronic devices in digital healthcare systems. |
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| ISSN: | 2397-4621 |