Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery
Background Acute kidney injury (AKI) is a common complication after pediatric cardiac surgery and is associated with worse outcomes. Ibuprofen is widely used in the perioperative period and can affect kidney function in children. However, the association between ibuprofen exposure and AKI after pedi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2318417 |
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| author | Sheng Shi Chao Xiong Dongyun Bie Zhongrong Fang Jianhui Wang |
| author_facet | Sheng Shi Chao Xiong Dongyun Bie Zhongrong Fang Jianhui Wang |
| author_sort | Sheng Shi |
| collection | DOAJ |
| description | Background Acute kidney injury (AKI) is a common complication after pediatric cardiac surgery and is associated with worse outcomes. Ibuprofen is widely used in the perioperative period and can affect kidney function in children. However, the association between ibuprofen exposure and AKI after pediatric cardiac surgery has not been determined yet.Methods In this retrospective cohort study, children undergoing cardiac surgery with cardiopulmonary bypass were studied. Exposure was defined as given ibuprofen in the first 7 days after surgery. Postoperative AKI was diagnosed using the KDIGO criteria. A multivariable Cox regression model was used to assess the association between ibuprofen exposure and postoperative AKI by taking ibuprofen as a time-varying covariate.Results Among 1,112 included children, 198 of them (17.8%) experienced AKI. In total, 396 children (35.6%) were exposed to ibuprofen. AKI occurred less frequently among children who were administered ibuprofen than among those who were not (46 of 396 [11.6%] vs. 152 of 716 [21.2%], p < 0.001). Using the Cox regression model accounting for time-varying exposures, ibuprofen treatment was not associated with AKI (adjusted HR, 0.99; 95% CI 0.70–1.39, p = 0.932). This insignificant association was consistent across the sensitivity and subgroup analyses.Conclusions Postoperative ibuprofen exposure in pediatric patients undergoing cardiac surgery was not associated with an increased risk of AKI. |
| format | Article |
| id | doaj-art-815afaa7ee884415881a2d81de498c74 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-815afaa7ee884415881a2d81de498c742025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2318417Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgerySheng Shi0Chao Xiong1Dongyun Bie2Zhongrong Fang3Jianhui Wang4Department of Anesthesiology, National Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Anesthesiology, National Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Anesthesiology, National Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Anesthesiology, National Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Anesthesiology, National Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBackground Acute kidney injury (AKI) is a common complication after pediatric cardiac surgery and is associated with worse outcomes. Ibuprofen is widely used in the perioperative period and can affect kidney function in children. However, the association between ibuprofen exposure and AKI after pediatric cardiac surgery has not been determined yet.Methods In this retrospective cohort study, children undergoing cardiac surgery with cardiopulmonary bypass were studied. Exposure was defined as given ibuprofen in the first 7 days after surgery. Postoperative AKI was diagnosed using the KDIGO criteria. A multivariable Cox regression model was used to assess the association between ibuprofen exposure and postoperative AKI by taking ibuprofen as a time-varying covariate.Results Among 1,112 included children, 198 of them (17.8%) experienced AKI. In total, 396 children (35.6%) were exposed to ibuprofen. AKI occurred less frequently among children who were administered ibuprofen than among those who were not (46 of 396 [11.6%] vs. 152 of 716 [21.2%], p < 0.001). Using the Cox regression model accounting for time-varying exposures, ibuprofen treatment was not associated with AKI (adjusted HR, 0.99; 95% CI 0.70–1.39, p = 0.932). This insignificant association was consistent across the sensitivity and subgroup analyses.Conclusions Postoperative ibuprofen exposure in pediatric patients undergoing cardiac surgery was not associated with an increased risk of AKI.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2318417Acute kidney injurycardiac surgeryibuprofenpediatrics |
| spellingShingle | Sheng Shi Chao Xiong Dongyun Bie Zhongrong Fang Jianhui Wang Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery Renal Failure Acute kidney injury cardiac surgery ibuprofen pediatrics |
| title | Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery |
| title_full | Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery |
| title_fullStr | Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery |
| title_full_unstemmed | Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery |
| title_short | Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery |
| title_sort | association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery |
| topic | Acute kidney injury cardiac surgery ibuprofen pediatrics |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2318417 |
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