Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function
Abstract Label-free optical imaging and sensing of single nanoparticles are vital for fundamental research, disease diagnosis, and nanomaterial studies. Surface plasmon resonance microscopy (SPRM) is a label-free detection technology which is widely used in the detection of single nanoparticles. How...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-60460-7 |
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| author | Xinxiang You Zetao Fan Hongli Zhang Zhibo Xie Chengen Li Huaqiao Gui Gang Zou Qiwen Zhan Jianguo Liu Xu Liu Douguo Zhang |
| author_facet | Xinxiang You Zetao Fan Hongli Zhang Zhibo Xie Chengen Li Huaqiao Gui Gang Zou Qiwen Zhan Jianguo Liu Xu Liu Douguo Zhang |
| author_sort | Xinxiang You |
| collection | DOAJ |
| description | Abstract Label-free optical imaging and sensing of single nanoparticles are vital for fundamental research, disease diagnosis, and nanomaterial studies. Surface plasmon resonance microscopy (SPRM) is a label-free detection technology which is widely used in the detection of single nanoparticles. However, conventional SPRM suffers from poor spatial resolution, a limited field-of-view, system complexity, and high operating costs. In this study, we introduce a compact, low-cost, and large field-of-view chip-based plasmonic scattering microscopy (Chip-PSM). Compared with SPRM, Chip-PSM retains high detection sensitivity and in situ label-free analysis capability, while offering a larger field-of-view, an isotropic point-spread-function and higher spatial resolution. With these advantages, Chip-PSM enables detecting and imaging dielectric nanoparticles, gold nanoparticles, and biological samples. Additionally, the hygroscopic growth dynamics of aerosol nanoparticles and the chemical reactions occurring on nanocrystals are successfully characterized via Chip-PSM. We anticipate that the proposed Chip-PSM will have broad applications across many scientific fields, including physics, chemistry, and atmospheric sciences. |
| format | Article |
| id | doaj-art-81527ff673d6459596bc4222a9b74de7 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-81527ff673d6459596bc4222a9b74de72025-08-20T02:30:42ZengNature PortfolioNature Communications2041-17232025-06-0116111110.1038/s41467-025-60460-7Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-functionXinxiang You0Zetao Fan1Hongli Zhang2Zhibo Xie3Chengen Li4Huaqiao Gui5Gang Zou6Qiwen Zhan7Jianguo Liu8Xu Liu9Douguo Zhang10Advanced Laser Technology Laboratory of Anhui Province, Department of Optics and Optical Engineering, University of Science and Technology of ChinaAdvanced Laser Technology Laboratory of Anhui Province, Department of Optics and Optical Engineering, University of Science and Technology of ChinaCAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of ChinaKey Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of SciencesAdvanced Laser Technology Laboratory of Anhui Province, Department of Optics and Optical Engineering, University of Science and Technology of ChinaKey Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of SciencesCAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of ChinaSchool of Optical-Electrical and Computer Engineering, University of Shanghai for Science and TechnologyKey Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of SciencesState Key Laboratory of Extreme Photonics and Instrumentation, College of Optical Science and Engineering, Zhejiang UniversityAdvanced Laser Technology Laboratory of Anhui Province, Department of Optics and Optical Engineering, University of Science and Technology of ChinaAbstract Label-free optical imaging and sensing of single nanoparticles are vital for fundamental research, disease diagnosis, and nanomaterial studies. Surface plasmon resonance microscopy (SPRM) is a label-free detection technology which is widely used in the detection of single nanoparticles. However, conventional SPRM suffers from poor spatial resolution, a limited field-of-view, system complexity, and high operating costs. In this study, we introduce a compact, low-cost, and large field-of-view chip-based plasmonic scattering microscopy (Chip-PSM). Compared with SPRM, Chip-PSM retains high detection sensitivity and in situ label-free analysis capability, while offering a larger field-of-view, an isotropic point-spread-function and higher spatial resolution. With these advantages, Chip-PSM enables detecting and imaging dielectric nanoparticles, gold nanoparticles, and biological samples. Additionally, the hygroscopic growth dynamics of aerosol nanoparticles and the chemical reactions occurring on nanocrystals are successfully characterized via Chip-PSM. We anticipate that the proposed Chip-PSM will have broad applications across many scientific fields, including physics, chemistry, and atmospheric sciences.https://doi.org/10.1038/s41467-025-60460-7 |
| spellingShingle | Xinxiang You Zetao Fan Hongli Zhang Zhibo Xie Chengen Li Huaqiao Gui Gang Zou Qiwen Zhan Jianguo Liu Xu Liu Douguo Zhang Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function Nature Communications |
| title | Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function |
| title_full | Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function |
| title_fullStr | Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function |
| title_full_unstemmed | Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function |
| title_short | Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function |
| title_sort | large field of view plasmonic scattering imaging and sensing of nanoparticles with isotropic point spread function |
| url | https://doi.org/10.1038/s41467-025-60460-7 |
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